National Cancer Control Institute, National Cancer Center, Goyang, 10408, South Korea.
Department of Family Medicine, Seoul National University Hospital, Seoul, 03080, South Korea.
Sci Rep. 2019 Apr 11;9(1):5951. doi: 10.1038/s41598-019-42398-1.
We assessed whether visceral adipose tissue (VAT) compared with subcutaneous adipose tissue (SAT) has modifying effects on the cross-sectional association between ambient air pollution and hypertension in Korean men. This study included 1,417 adult men who visited a health checkup center. Abdominal fat depots were measured by computed tomography, and we used the annual average concentrations of ambient air pollutants such as particulate matter with an aerodynamic diameter of ≤10 μm (PM), nitrogen dioxide, sulfur dioxide, and carbon monoxide (CO). The annual mean concentrations of PM (odds ratio [OR] = 1.30; 95% confidence interval [CI] = 1.12-1.52) and CO (OR = 1.20; 95% CI = 1.03-1.39) showed a positive association with hypertension. In particular, modifying effects on hypertension were found between PM and VAT-related traits such as VAT and visceral-to-subcutaneous fat ratio (VSR). The association between PM and hypertension was much stronger in the high-VAT (OR = 1.74; 95% CI = 1.12-2.71) and high-VSR groups (OR = 1.53; 95% CI = 1.23-1.91). However, the strength of association across levels of SAT was not observed (P = 0.4615). In conclusion, we found that association between PM exposure and hypertension is different by abdominal fat distribution.
我们评估了内脏脂肪组织 (VAT) 与皮下脂肪组织 (SAT) 相比，是否会改变环境空气污染与韩国男性高血压之间的横断面关联。本研究纳入了 1417 名成年男性，他们曾到健康检查中心就诊。腹部脂肪组织通过计算机断层扫描进行测量，我们使用了环境空气污染物（如直径≤10μm 的颗粒物、二氧化氮、二氧化硫和一氧化碳）的年平均浓度。PM （比值比 [OR] = 1.30；95%置信区间 [CI] = 1.12-1.52）和 CO（OR = 1.20；95% CI = 1.03-1.39）的年平均浓度与高血压呈正相关。特别是，PM 与 VAT 相关特征（如 VAT 和内脏脂肪与皮下脂肪比值 [VSR]）之间的相互作用对高血压有影响。PM 与高血压之间的关联在高 VAT（OR = 1.74；95% CI = 1.12-2.71）和高 VSR 组（OR = 1.53；95% CI = 1.23-1.91）中更为显著。然而，在 SAT 水平上，并未观察到关联的强度差异（P = 0.4615）。总之，我们发现 PM 暴露与高血压之间的关联因腹部脂肪分布而异。
