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J Bone Joint Surg Br. 2011 Jan;93(1):52-6. doi: 10.1302/0301-620X.93B1.24788.
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Flexible intramedullary nail use in limb lengthening.弹性髓内钉在肢体延长中的应用。
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Computer-aided methods for assessing lower limb deformities in orthopaedic surgery planning.计算机辅助方法评估矫形外科手术规划中的下肢畸形。
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Deformity correction in children with hereditary hypophosphatemic rickets.遗传性低磷性佝偻病患儿的畸形矫正
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In utero physiology: role in nutrient delivery and fetal development for calcium, phosphorus, and vitamin D.子宫内生理学：钙、磷和维生素D在营养物质输送及胎儿发育中的作用
Am J Clin Nutr. 2007 Feb;85(2):604S-607S. doi: 10.1093/ajcn/85.2.604S.
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Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.DMP1缺失会导致佝偻病和骨软化症，并揭示了骨细胞在矿物质代谢中的作用。
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Resurrection of vitamin D deficiency and rickets.维生素D缺乏症和佝偻病的再度出现。
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8
Deformity correction by external fixation and/or intramedullary nailing in hypophosphatemic rickets.低磷性佝偻病的外固定和/或髓内钉固定畸形矫正术
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Nutritional rickets around the world: causes and future directions.全球营养性佝偻病：病因与未来方向
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Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice.饮食和血清磷调节小鼠成纤维细胞生长因子23的表达及1,25-二羟基维生素D的代谢。
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利用诊断成像技术检测维生素D抵抗性佝偻病患者治疗中反复出现畸形的原因。

Detecting reasons for recurrent deformity in treatment of patients with vitamin D-resistant rickets using diagnostic imaging.

作者信息

Diachkova Galina Viktorovna, Novikov Konstantin Igorevich, Effatparvar Mohammad Reza, Chistova Elena Aleksandrovna, Diachkov Konstantin Aleksandrovich, Novikova Olga Stepanovna, Korkin Anatoly Yakovlevich, Shikhaleva Natalia Gennadyevna

机构信息

X-ray Department, Russian Ilizarov Scientific Centre "Restorative Traumatology and Orthopaedics", ul.M.Ulianovoy, Kurgan, 640014, Russia.

Trauma and Orthopaedic Department No.18, ul.M.Ulianovoy, Kurgan, 640014, Russia.

出版信息

J Orthop. 2019 Mar 22;16(4):325-328. doi: 10.1016/j.jor.2019.02.033. eCollection 2019 Jul-Aug.

DOI:10.1016/j.jor.2019.02.033
PMID:30976148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6441721/
Abstract

PURPOSE

To assess age related manifestations of the femur and tibia in patients with vitamin D-resistant rickets (VDR) and explore causes for recurrent deformity using imaging modalities.

METHODS

Computed tomography (CT), magnetic resonance imaging (MRI) and dual energy X-ray densitometry (DEXA) were used to assess conditions of long bones of lower limbs in patients with vitamin D-resistant rickets aged from 4 years to 30 years preoperatively and after limb lengthening.

RESULTS

Age related MRI findings showed specific structure of the femur and tibia in patients with VDR preoperatively and after operative treatment. Abundant irregular osteoid formed in femoral and tibial physes was shown to reveal complicated nature of bone deformity causing recurrence in patients with VDR at childhood. CT findings allowed us to detect early cortical injury, measure its length with forming Looser's zones, examine significant differences in density measurements of Looser's zones preoperatively and after deformity correction using transosseous osteosynthesis.

CONCLUSION

Recurrent deformity can develop in patients with VDR due to progression of the disease, irregular osteoid deposited in the medial and lateral metaepiphysis, osteoid area measuring over 50% of epiphyseal cross section, insufficient regenerate mineralization, and formation of Looser's zones.

摘要

目的

评估维生素D抵抗性佝偻病（VDR）患者股骨和胫骨的年龄相关表现，并使用影像学方法探讨畸形复发的原因。

方法

采用计算机断层扫描（CT）、磁共振成像（MRI）和双能X线骨密度仪（DEXA）对4至30岁维生素D抵抗性佝偻病患者术前及肢体延长术后下肢长骨情况进行评估。

结果

年龄相关的MRI表现显示了VDR患者术前及手术治疗后股骨和胫骨的特定结构。股骨和胫骨骨骺中形成的大量不规则类骨质表明儿童期VDR患者骨畸形复发的复杂性。CT表现使我们能够检测早期皮质损伤，测量其长度并形成假骨折线，检查术前及使用经骨内固定矫正畸形后假骨折线密度测量的显著差异。

结论

VDR患者可因疾病进展、内外侧干骺端沉积不规则类骨质、类骨质面积超过骨骺横截面的50%、再生矿化不足以及假骨折线的形成而出现畸形复发。