Pleskova S N, Kriukov R N, Gorshkova E N, Boryakov A V
Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, 603950, Russia.
R.E. Alekseev Nizhny Novgorod Technical State University, Nizhny Novgorod, 603950, Russia.
Heliyon. 2019 Mar 28;5(3):e01439. doi: 10.1016/j.heliyon.2019.e01439. eCollection 2019 Mar.
This article describes the main morphological and biochemical features of neutrophil granulocytes in the process of phagocytosis of two types of quantum dots (CdSe/ZnS-MPA and CdSe/CdSeZnS/ZnS-PTVP). This study is the first to observe the transfer of large aggregates of quantum dots through neutrophils. During this process the cells demonstrate high chemotactic activity. Furthermore, neutrophil pseudopodia underwent alterations during the early stages of phagocytosis. The findings demonstrated that the biochemical profile of neutrophils is practically identical after phagocytosis of both types of quantum dots, but differs significantly from neutrophil metabolism after bacterial phagocytosis.
本文描述了中性粒细胞在吞噬两种量子点（CdSe/ZnS-MPA和CdSe/CdSeZnS/ZnS-PTVP）过程中的主要形态和生化特征。本研究首次观察到大量量子点聚集体通过中性粒细胞的转移。在此过程中，细胞表现出高趋化活性。此外，中性粒细胞伪足在吞噬早期发生了改变。研究结果表明，吞噬两种量子点后中性粒细胞的生化特征实际上是相同的，但与吞噬细菌后中性粒细胞的代谢有显著差异。
