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Molecular regulation of the renin-angiotensin system by sodium-glucose cotransporter 2 inhibition in type 1 diabetes mellitus.

作者信息

Kopecky Chantal, Lytvyn Yuliya, Domenig Oliver, Antlanger Marlies, Kovarik Johannes J, Kaltenecker Christopher C, Poglitsch Marko, Perkins Bruce A, Rye Kerry-Anne, Cherney David Z I, Säemann Marcus D

机构信息

School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Level 2 Lowy Cancer Research Centre, High Street Gate 9, Sydney, NSW, 2052, Australia.

Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.

出版信息

Diabetologia. 2019 Jun;62(6):1090-1093. doi: 10.1007/s00125-019-4871-8. Epub 2019 Apr 11.

DOI:10.1007/s00125-019-4871-8
PMID:30976852
Abstract
摘要

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引用本文的文献

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Physiol Rep. 2025 Aug;13(16):e70465. doi: 10.14814/phy2.70465.
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SGLT2 inhibition promotes glomerular repopulation by cells of renin lineage in experimental kidney disease.SGLT2 抑制通过肾素谱系细胞促进实验性肾病中的肾小球再殖。
Acta Physiol (Oxf). 2024 Mar;240(3):e14108. doi: 10.1111/apha.14108. Epub 2024 Feb 5.
3
Interactive Effects of Empagliflozin and Hyperglycemia on Urinary Amino Acids in Individuals With Type 1 Diabetes.

本文引用的文献

1
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.卡格列净与 2 型糖尿病的心血管和肾脏事件。
N Engl J Med. 2017 Aug 17;377(7):644-657. doi: 10.1056/NEJMoa1611925. Epub 2017 Jun 12.
2
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.钠-葡萄糖协同转运蛋白2抑制剂在糖尿病治疗中的应用：心血管和肾脏效应、潜在机制及临床应用
Circulation. 2016 Sep 6;134(10):752-72. doi: 10.1161/CIRCULATIONAHA.116.021887. Epub 2016 Jul 28.
3
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.
恩格列净与高血糖对 1 型糖尿病个体尿液氨基酸的交互作用。
Diabetes. 2024 Mar 1;73(3):401-411. doi: 10.2337/db23-0694.
4
Does Dapagliflozin influence arterial stiffness and levels of circulating anti-aging hormone soluble Klotho in people with type 2 diabetes and kidney disease? Results of a randomized parallel group clinical trial.达格列净对2型糖尿病合并肾病患者的动脉僵硬度及循环中抗衰老激素可溶性klotho水平有影响吗？一项随机平行组临床试验的结果。
Front Cardiovasc Med. 2022 Sep 30;9:992327. doi: 10.3389/fcvm.2022.992327. eCollection 2022.
5
SGLT2 Inhibition in Type 1 Diabetes with Diabetic Kidney Disease: Potential Cardiorenal Benefits Can Outweigh Preventable Risk of Diabetic Ketoacidosis.SGLT2 抑制剂在伴有糖尿病肾病的 1 型糖尿病中的应用：潜在的心肾获益可能超过可预防的糖尿病酮症酸中毒风险。
Curr Diab Rep. 2022 Jul;22(7):317-332. doi: 10.1007/s11892-022-01471-2. Epub 2022 May 28.
6
Empagliflozin Alleviates Left Ventricle Hypertrophy in High-Fat-Fed Mice by Modulating Renin Angiotensin Pathway.恩格列净通过调节肾素-血管紧张素通路缓解高脂喂养小鼠的左心室肥厚。
J Renin Angiotensin Aldosterone Syst. 2022 Jan 18;2022:8861911. doi: 10.1155/2022/8861911. eCollection 2022.
7
Combined sodium glucose co-transporter-2 inhibitor and angiotensin-converting enzyme inhibition upregulates the renin-angiotensin system in chronic kidney disease with type 2 diabetes: Results of a randomized, double-blind, placebo-controlled exploratory trial.联合钠-葡萄糖共转运蛋白 2 抑制剂和血管紧张素转换酶抑制剂上调 2 型糖尿病慢性肾脏病中的肾素-血管紧张素系统：一项随机、双盲、安慰剂对照的探索性试验结果。
Diabetes Obes Metab. 2022 May;24(5):816-826. doi: 10.1111/dom.14639. Epub 2022 Jan 24.
8
Cardiorenal Protection in Diabetic Kidney Disease.糖尿病肾病中的心脏肾脏保护
Endocrinol Metab (Seoul). 2021 Apr;36(2):256-269. doi: 10.3803/EnM.2021.987. Epub 2021 Apr 19.
9
Making a case for the combined use of SGLT2 inhibitors and GLP1 receptor agonists for cardiorenal protection.主张联合使用 SGLT2 抑制剂和 GLP1 受体激动剂进行心脏肾保护。
J Bras Nefrol. 2020 Oct-Dec;42(4):467-477. doi: 10.1590/2175-8239-JBN-2020-0100.
10
Comparison of mechanisms and transferability of outcomes of SGLT2 inhibition between type 1 and type 2 diabetes.1型糖尿病与2型糖尿病中SGLT2抑制作用机制及结局可转移性的比较
Endocrinol Diabetes Metab. 2020 Apr 24;3(3):e00129. doi: 10.1002/edm2.129. eCollection 2020 Jul.
恩格列净与 2 型糖尿病患者的肾脏疾病进展。
N Engl J Med. 2016 Jul 28;375(4):323-34. doi: 10.1056/NEJMoa1515920. Epub 2016 Jun 14.
4
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.恩格列净：在 2 型糖尿病中的心血管结局和死亡率。
N Engl J Med. 2015 Nov 26;373(22):2117-28. doi: 10.1056/NEJMoa1504720. Epub 2015 Sep 17.
5
Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats.与单独阻断 AT1 受体相比，最佳的 AT1 受体-脑啡肽酶抑制在高血压大鼠中具有更优的心脏保护作用。
Kidney Int. 2015 Jul;88(1):109-20. doi: 10.1038/ki.2015.107. Epub 2015 Apr 1.
6
Sodium glucose cotransport-2 inhibition and intrarenal RAS activity in people with type 1 diabetes.1型糖尿病患者中钠-葡萄糖协同转运蛋白2抑制与肾内肾素-血管紧张素系统活性
Kidney Int. 2014 Nov;86(5):1057-8. doi: 10.1038/ki.2014.246.
7
Guidelines for managing high blood pressure.高血压管理指南。
JAMA. 2014 Jul 16;312(3):294-5. doi: 10.1001/jama.2014.6593.
8
Molecular mechanisms of diabetic kidney disease.糖尿病肾病的分子机制。
J Clin Invest. 2014 Jun;124(6):2333-40. doi: 10.1172/JCI72271. Epub 2014 Jun 2.
9
Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus.1 型糖尿病患者钠-葡萄糖共转运蛋白 2 抑制剂的肾脏血流动力学效应。
Circulation. 2014 Feb 4;129(5):587-97. doi: 10.1161/CIRCULATIONAHA.113.005081. Epub 2013 Dec 13.