Hajós M, Engberg G
Psychopharmacology (Berl). 1986;90(2):170-2. doi: 10.1007/BF00181235.
Basal body temperature of spontaneously hypertensive rats (SHR) was found to be significantly elevated compared to normotensive Wistar Kyoto rats (WKR). The hypothermic response to low doses of the alpha 2-receptor agonist clonidine was significantly smaller in SHR compared to WKR. In contrast, the thermoregulatory response of SHR to a non-noxious stressor was heightened. We propose that the elevated basal temperature observed in SHR is not due to an impaired thermolysis but the result of a noradrenaline-mediated hyperreactivity to environmental stress, e.g. handling of the animals during the temperature measurement procedure.
与正常血压的Wistar Kyoto大鼠（WKR）相比，自发性高血压大鼠（SHR）的基础体温显著升高。与WKR相比，SHR对低剂量α2受体激动剂可乐定的低温反应显著更小。相反，SHR对非有害应激源的体温调节反应增强。我们认为，SHR中观察到的基础体温升高不是由于热解受损，而是去甲肾上腺素介导的对环境应激（如在体温测量过程中处理动物）的高反应性的结果。
