Wright G, Iams S, Knecht E
Can J Physiol Pharmacol. 1977 Oct;55(5):975-82. doi: 10.1139/y77-134.
Thermal resistance as determined by survival time was examined in different age groups of spontaneously hypertensive (SHR) rats during terminal heating. A comparison with age or weight matched controls indicated that the thermal resistance of SHR animals was markedly inferior to that of normotensive animals as evidenced by 56% and 36% decreases in the total heating time to the lethal temperature, respectively. The decrease in thermal resistance in SHR animals occurred after 8 weeks of age and was coincident with the elevation of mean blood pressure to about 150 mmHg. The observation of significantly decreased total body water and rates of evaporation at critical colonic temperatures (39-40 degrees C) suggested the possibility of a reduced ability for water mobilization for thermoregulatory purposes in hypertensive animals although it appeared that other factors affecting heat gain or loss were involved.
在终末加热期间，对不同年龄组的自发性高血压（SHR）大鼠通过存活时间测定热抵抗力。与年龄或体重匹配的对照组相比表明，SHR动物的热抵抗力明显低于正常血压动物，分别达到致死温度的总加热时间减少56%和36%即可证明。SHR动物热抵抗力的降低在8周龄后出现，并且与平均血压升高至约150 mmHg同时发生。在临界结肠温度（39 - 40摄氏度）下观察到全身水量显著减少和蒸发速率降低，这表明高血压动物为体温调节目的调动水分的能力可能降低，尽管似乎还涉及其他影响热量得失的因素。
