Willner P, Wise D, Ellis T
Psychopharmacology (Berl). 1986;90(2):229-35. doi: 10.1007/BF00181247.
Three groups of rats were required to locate a single water bottle from an octagonal array of eight otherwise empty bottles. For one group (place navigation) the goal bottle remained in the same place from trial to trial; for a second group (cue navigation) the position of the goal bottle was cued by a black card over the nozzle; for the third group the goal bottle was uncued and moved randomly from trial to trial. Place and cue groups improved more than controls on all measures of performance. Scopolamine (0.2 mg/kg) substantially impaired performance in the place group, but had no effect on either of the other groups; the peripherally acting anticholinergic drug meth-scopolamine (0.2 mg/kg) had no effect in any group. In a second experiment, using food rewards, scopolamine caused a dose-dependent impairment of place navigation at doses from 0.025 to 0.4 mg/kg; 0.4 mg/kg also impaired cue navigation, but at this dose behaviour was visibly abnormal. In both experiments, scopolamine primarily affected speed of performance rather than accuracy. Olfactory cues were shown not to contribute to performance in either group. The results implicate central cholinergic transmission in the processing of visuo-spatial information.
三组大鼠需要从由八个空瓶子组成的八角形阵列中找到唯一的一个水瓶。对于一组（位置导航组），目标瓶在每次试验中都保持在同一位置；对于第二组（线索导航组），目标瓶的位置由喷嘴上方的一张黑卡提示；对于第三组，目标瓶没有提示，并且每次试验都随机移动。在所有性能指标上，位置导航组和线索导航组的表现都比对照组有更大提升。东莨菪碱（0.2毫克/千克）显著损害了位置导航组的表现，但对其他两组均无影响；外周作用的抗胆碱能药物甲基东莨菪碱（0.2毫克/千克）对任何一组都没有影响。在第二个实验中，使用食物奖励，东莨菪碱在0.025至0.4毫克/千克的剂量范围内导致位置导航出现剂量依赖性损害；0.4毫克/千克也损害了线索导航，但在此剂量下行为明显异常。在两个实验中，东莨菪碱主要影响表现速度而非准确性。嗅觉线索在两组中均未显示对表现有贡献。结果表明中枢胆碱能传递参与视觉空间信息的处理。
