阿尔茨海默病患者外周血细胞中神经生长因子受体 p75mRNA 水平。
Neurotrophin Receptor p75 mRNA Level in Peripheral Blood Cells of Patients with Alzheimer's Disease.
机构信息
Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Department of Geriatrics, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China.
出版信息
Neurotox Res. 2019 Jul;36(1):101-107. doi: 10.1007/s12640-019-00035-9. Epub 2019 Apr 11.
The neurotrophin receptor p75 (p75NTR) plays important roles in regulating amyloid-beta (Aβ) metabolism in the brain. The expression of p75NTR is altered in the brain of patients with Alzheimer's disease (AD). In this study, we aimed to evaluate whether p75NTR mRNA level in the peripheral blood cells is changed among AD patients and its potential to be a biomarker for AD. The study subjects included 26 patients with AD (PiB-PET positive) and 28 cognitively normal controls (PiB-PET negative). RNA was extracted from peripheral blood cells of fast blood. p75NTR mRNA was measured using quantitative real-time PCR assay. p75NTR mRNA levels in blood cells were comparable between AD patients and controls. p75NTR mRNA levels in blood cells were not correlated with MMSE scores, ApoE genotypes, gender, and age. p75NTR mRNA expression in blood cells is not changed in AD patients and is unlikely to be a biomarker for AD.
神经营养因子受体 p75（p75NTR）在调节大脑中的淀粉样β（Aβ）代谢中发挥重要作用。阿尔茨海默病（AD）患者大脑中的 p75NTR 表达发生改变。在这项研究中，我们旨在评估 AD 患者外周血单个核细胞中的 p75NTR mRNA 水平是否发生变化及其是否可能成为 AD 的生物标志物。研究对象包括 26 名 AD 患者（PiB-PET 阳性）和 28 名认知正常对照者（PiB-PET 阴性）。从快速血液中提取外周血单个核细胞中的 RNA。使用定量实时 PCR 测定法测量 p75NTR mRNA。AD 患者和对照组之间的血细胞中 p75NTR mRNA 水平相当。血细胞中的 p75NTR mRNA 水平与 MMSE 评分、ApoE 基因型、性别和年龄无关。AD 患者的血细胞中 p75NTR mRNA 表达没有改变，不太可能成为 AD 的生物标志物。
Zotero 插件