1 IRCCS Santa Maria Nascente - Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
2 Italian Scientific Spine Institute (ISICO), Milan, Italy.
Clin Rehabil. 2019 Aug;33(8):1404-1415. doi: 10.1177/0269215519842246. Epub 2019 Apr 12.
To compare the validity of the Italian Spine Youth Quality of Life (ISYQOL) questionnaire with that of the Scoliosis Research Society 22 (SRS22) questionnaire, the criterion standard for health-related quality of life (HRQOL) measurement in adolescents with spinal deformities.
Cross-sectional study.
Outpatient clinic.
Consecutive adolescents (10-18 years; 541 wearing brace) affected by idiopathic scoliosis (642 females, 100 males) or hyperkyphosis (87 females, 109 males).
NA.
The Spearman's correlation coefficient (rho) between ISYQOL and SRS22 was used to assess ISYQOL concurrent validity. Sex, age, severity, bracing, trunk appearance and deformity type were assessed for known-groups validity. Cohen's quantified between-groups differences. Multiple linear regression exploring the effect of sex, age, body mass index (BMI), severity, bone age, trunk appearance, physiotherapy, bracing and sport on HRQOL of scoliosis patients was used to assess concurrent validity further.
Satisfactory correlations were found between ISYQOL and SRS22 (scoliosis, rho = 0.71; kyphosis, rho = 0.56). Known-groups validity analysis showed that ISYQOL detects all the between-groups differences detected by SRS22 and a males-females difference undetected by SRS22. ISYQOL Cohen's was larger than SRS22 Cohen's in three between-groups comparisons and similar in the others. Brace, sport and scoliosis severity were independently related to ISYQOL (linear regression: = 0.23; < 0.001). Brace, sport and physiotherapy were related to SRS22 ( = 0.17).
ISYQOL showed high validity when used to measure HRQOL in adolescents with spinal deformities. Moreover, ISYQOL performs better than SRS22, having better known-groups validity and (contrary to SRS22) detecting the impact of disease severity on HRQOL.
比较意大利脊柱青年生活质量问卷（ISYQOL）与脊柱侧凸研究协会 22 项问卷（SRS22）的有效性，SRS22 是评估脊柱畸形青少年健康相关生活质量（HRQOL）的标准。
横断面研究。
门诊。
连续就诊的青少年（10-18 岁；541 人佩戴支具），患有特发性脊柱侧凸（642 名女性，100 名男性）或脊柱后凸（87 名女性，109 名男性）。
无。
使用 Spearman 相关系数（rho）评估 ISYQOL 与 SRS22 的相关性，以评估 ISYQOL 的同时效度。对性别、年龄、严重程度、支具、躯干外观和畸形类型进行评估，以评估已知组别的有效性。Cohen's 用于量化组间差异。使用多元线性回归模型进一步探讨性别、年龄、体重指数（BMI）、严重程度、骨龄、躯干外观、物理治疗、支具和运动对脊柱侧凸患者 HRQOL 的影响，以评估同时效度。
ISYQOL 与 SRS22 之间存在良好的相关性（脊柱侧凸，rho = 0.71；脊柱后凸，rho = 0.56）。已知组别的有效性分析表明，ISYQOL 可以检测到 SRS22 检测到的所有组间差异，以及 SRS22 检测不到的男性与女性之间的差异。在三个组间比较中，ISYQOL 的 Cohen's 大于 SRS22 的 Cohen's ，而在其他比较中则相似。支具、运动和脊柱侧凸严重程度与 ISYQOL 独立相关（线性回归：β = 0.23；< 0.001）。支具、运动和物理治疗与 SRS22 相关（β = 0.17）。
ISYQOL 用于评估脊柱畸形青少年的 HRQOL 时具有较高的有效性。此外，ISYQOL 比 SRS22 具有更好的有效性，具有更好的已知组间差异，并且（与 SRS22 相反）检测到疾病严重程度对 HRQOL 的影响。
