[胆碱能和血清素能过程在调节负强化系统活动中的作用]

[Role of cholinergic and serotoninergic processes in modulating the activity of the negative reinforcement system].

作者信息

Andreev B V

出版信息

Biull Eksp Biol Med. 1978 Nov;86(11):552-4.

Abstract

The influence of choline- and serotoninergic drugs upon the latency of switching off the central aversive stimulation was investigated. Physostigmine and fluoxetine were shown to increase the latency of escape. Scopolamine and p-chloroamphetamine could both increase the time of active escape and decrease it. Fluoxetine diminished the activation effect and inversed the inhibitory effect of scopolamine. Fluoxetine potentiated the inhibitory action of physostigmine. p-Chloroamphetamine attenuated the inhibitory effect of physostigmine and increased scopolamine effect. It is suggested that choline- and serotoninergic mechanisms depressed the activity of the negative reinforcement system. Functional interaction is postulated between these neuromediator systems.

摘要

研究了胆碱能和血清素能药物对消除中枢厌恶刺激潜伏期的影响。结果表明，毒扁豆碱和氟西汀可延长逃避潜伏期。东莨菪碱和对氯苯丙胺既能增加主动逃避时间，也能减少主动逃避时间。氟西汀减弱了激活作用，并逆转了东莨菪碱的抑制作用。氟西汀增强了毒扁豆碱的抑制作用。对氯苯丙胺减弱了毒扁豆碱的抑制作用，并增强了东莨菪碱的作用。提示胆碱能和血清素能机制抑制了负强化系统的活动。推测这些神经介质系统之间存在功能相互作用。