Hempleman S C, Adamson T P, Burger R E
Respir Physiol. 1986 Oct;66(1):53-60. doi: 10.1016/0034-5687(86)90138-6.
To investigate the response of individual intrapulmonary chemoreceptors (IPC) to venous CO2 loads approximating moderate muscular exercise, we recorded vagal discharge from 33 IPC arising from the left lungs of 9 anesthetized, unidirectionally ventilated Pekin ducks. Each IPC was studied during control conditions (PECO2 = 29.0 +/- 0.8 Torr, PVCO2 = 30.2 +/- 0.6 Torr) and during venous CO2 load (PECO2 = 29.5 +/- 0.7 Torr, PVCO2 = 51.5 +/- 1.4 Torr). Venous loading was produced by increasing the percentage of CO2 in the gas ventilating the right lung from 0 to 9-25% CO2. The flow of 1% CO2 through the left lung was adjusted to keep the left lung PECO2 constant. During venous loading, discharge frequencies indicated that the PCO2 at the receptive sites fell, on the average, 1.6 +/- 0.8 Torr.
为了研究个体肺内化学感受器（IPC）对接近中等强度肌肉运动时静脉血二氧化碳负荷的反应，我们记录了9只麻醉、单向通气的北京鸭左肺中33个IPC的迷走神经放电。在对照条件下（呼气末二氧化碳分压[PECO2]=29.0±0.8托，肺静脉二氧化碳分压[PVCO2]=30.2±0.6托）和静脉血二氧化碳负荷期间（PECO2=29.5±0.7托，PVCO2=51.5±1.4托）对每个IPC进行研究。通过将通气右肺的气体中二氧化碳百分比从0增加到9%-25%二氧化碳来产生静脉血负荷。调节1%二氧化碳通过左肺的流量以保持左肺PECO2恒定。在静脉血负荷期间，放电频率表明感受部位的二氧化碳分压平均下降1.6±0.8托。
