鸭肺内化学感受器对PCO₂和pH变化的反应。

Response of intrapulmonary chemoreceptors in the duck to changes in PCO2 and pH.

作者信息

Powell F L, Gratz R K, Scheid P

出版信息

Respir Physiol. 1978 Oct;35(1):65-77. doi: 10.1016/0034-5687(78)90042-7.

Abstract

We have estimated the relative importance of changes in blood PCO2 and pH in determining activity of intrapulmonary chemoreceptors (IPC) in the unidirectionally ventilated duck. The response of single unit vagal afferents from IPC to changing lung gas PCO2 was tested before and after changing blood pH by intravenous infusion of NaHCO3. Using multiple linear regression analysis, we calculated how much of the change in IPC activity for a given change in PCO2 was due to the changing PCO2 at constant pH (CO2 sensitivity) or to the change in pH concomitant with the change in PCO2 (H+ sensitivity). For 10 IPC, the CO2 sensitivity was on the average 2.3 times larger than the H+ sensitivity. Changes in pH as well as PCO2 of lung blood should be considered in assessing the role of IPC in control of breathing.

摘要

我们估算了血液PCO₂和pH值变化在决定单向通气鸭肺内化学感受器（IPC）活性方面的相对重要性。在通过静脉输注NaHCO₃改变血液pH值之前和之后，测试了来自IPC的单单位迷走神经传入纤维对肺气体PCO₂变化的反应。使用多元线性回归分析，我们计算了在给定的PCO₂变化中，有多少IPC活性的变化是由于在恒定pH值下PCO₂的变化（CO₂敏感性），或者是由于与PCO₂变化同时发生的pH值变化（H⁺敏感性）。对于10个IPC，CO₂敏感性平均比H⁺敏感性大2.3倍。在评估IPC在呼吸控制中的作用时，应考虑肺血pH值以及PCO₂的变化。