镁催化的末端炔烃和内炔烃的硼氢化反应
Magnesium-Catalyzed Hydroboration of Terminal and Internal Alkynes.
作者信息
Magre Marc, Maity Bholanath, Falconnet Alban, Cavallo Luigi, Rueping Magnus
机构信息
Institute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074, Aachen, Germany.
KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
出版信息
Angew Chem Int Ed Engl. 2019 May 20;58(21):7025-7029. doi: 10.1002/anie.201902188. Epub 2019 Apr 12.
A magnesium-catalyzed hydroboration of alkynes providing good yields and selectivities for a wide range of terminal and symmetrical and unsymmetrical internal alkynes has been developed. The compatibility with many functional groups makes this magnesium catalyzed procedure attractive for late stage functionalization. Experimental mechanistic investigations and DFT calculations reveal insights into the reaction mechanism of the magnesium catalyzed protocol.
已开发出一种镁催化的炔烃硼氢化反应，该反应对于多种末端炔烃、对称和不对称内炔烃都能提供良好的产率和选择性。与许多官能团的兼容性使得这种镁催化方法在后期官能化反应中颇具吸引力。实验机理研究和密度泛函理论（DFT）计算揭示了镁催化反应过程的反应机理。
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