维拉帕米和色甘酸钠对哮喘患者白三烯D4诱导的支气管收缩的作用。
Effect of verapamil and sodium cromoglycate on leukotriene D4 induced bronchoconstriction in patients with asthma.
作者信息
Roberts J A, Rodger I W, Thomson N C
出版信息
Thorax. 1986 Oct;41(10):753-8. doi: 10.1136/thx.41.10.753.
Leukotriene D4 (LTD4) may be an important mediator in asthma. The effect of verapamil and sodium cromoglycate on LTD4 induced bronchoconstriction has been examined in seven patients with asthma. The bronchoconstrictor response to increasing concentrations of inhaled LTD4 (0.0032-50 micrograms/ml) was assessed by measuring changes in FEV1, specific airways conductance, and flow rate at 30% of vital capacity (V30(p)). Results were expressed as the provocation concentration (PC) producing a 10% fall in FEV1 (PC10FEV1), a 35% fall in specific airways conductance (PC35SGaw), and a 30% fall in flow at 30% of vital capacity (PC30 V30(p)). Neither verapamil nor cromoglycate inhibited LTD4 induced bronchoconstriction in asthmatic subjects. These results suggest that in asthmatic patients LTD4 induced bronchoconstriction is not mediated via verapamil or cromoglycate sensitive mechanisms.
白三烯 D4（LTD4）可能是哮喘的一种重要介质。已在 7 例哮喘患者中研究了维拉帕米和色甘酸钠对 LTD4 诱导的支气管收缩的影响。通过测量第一秒用力呼气容积（FEV1）、比气道传导率以及肺活量 30%时的流速（V30(p)）的变化，评估对递增浓度吸入 LTD4（0.0032 - 50 微克/毫升）的支气管收缩反应。结果以导致 FEV1 下降 10%的激发浓度（PC）（PC10FEV1）、比气道传导率下降 35%的激发浓度（PC35SGaw）以及肺活量 30%时流速下降 30%的激发浓度（PC30 V30(p)）来表示。维拉帕米和色甘酸钠均未抑制哮喘患者中 LTD4 诱导的支气管收缩。这些结果表明，在哮喘患者中，LTD4 诱导的支气管收缩不是通过维拉帕米或色甘酸钠敏感机制介导的。
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