Hirshman C A, Darnell M, Brugman T, Peters J
Prostaglandins. 1983 Apr;25(4):481-90. doi: 10.1016/0090-6980(83)90020-5.
Leukotriene D4 (5 micrograms/ml) aerosol constricts airways of dogs with nonspecific airway hyperreactivity but not of mongrel dogs which lack nonspecific airway hyperreactivity. RL increased 200 +/- 25% and Cdyn decreased to 77 +/- 5% of the prechallenge value. LTD4 (10 micrograms/ml) produced no further increase. Atropine (0.2 mg/kg) prevented the increase in RL and decrease in Cdyn, suggesting that part of the effect of LTD4 on airways is neurally mediated.
白三烯D4（5微克/毫升）气雾剂可使具有非特异性气道高反应性的犬类气道收缩，但对缺乏非特异性气道高反应性的杂种犬则无此作用。气道阻力（RL）增加200±25%，动态顺应性（Cdyn）降至激发前值的77±5%。白三烯D4（10微克/毫升）未产生进一步增加。阿托品（0.2毫克/千克）可防止气道阻力增加和动态顺应性降低，这表明白三烯D4对气道的部分作用是由神经介导的。
