Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.
Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA.
Genes (Basel). 2019 Apr 11;10(4):295. doi: 10.3390/genes10040295.
Exercise is one of the best nonpharmacologic therapies to treat hypertension. The blood pressure (BP) response to exercise is heritable. Yet, the genetic basis for the antihypertensive effects of exercise remains elusive. To assemble a prioritized gene signature, we performed a systematic review with a series of Boolean searches in PubMed (including Medline) from earliest coverage. The inclusion criteria were human genes in major BP regulatory pathways reported to be associated with: (1) the BP response to exercise; (2) hypertension in genome-wide association studies (GWAS); (3) the BP response to pharmacotherapy; (4a) physical activity and/or obesity in GWAS; and (4b) BP, physical activity, and/or obesity in non-GWAS. Included GWAS reports disclosed the statistically significant thresholds used for multiple testing. The search yielded 1422 reports. Of these, 57 trials qualified from which we extracted 11 genes under criteria 1, 18 genes under criteria 2, 28 genes under criteria 3, 27 genes under criteria 4a, and 29 genes under criteria 4b. We also included 41 genes identified from our previous work. Deep-sequencing the exons of this systematically assembled signature of genes represents a cost and time efficient approach to investigate the genomic basis for the antihypertensive effects of exercise.
运动是治疗高血压的最佳非药物疗法之一。运动对血压的影响具有遗传性。然而，运动对血压的降压作用的遗传基础仍难以捉摸。为了构建一个优先的基因特征集，我们在 PubMed（包括 Medline）中进行了系统的文献综述，并进行了一系列布尔搜索，最早的检索时间是从那时开始。纳入标准是主要血压调节途径中的人类基因，这些基因与以下方面有关：（1）运动对血压的反应；（2）全基因组关联研究（GWAS）中的高血压；（3）药物治疗对血压的反应；（4a）GWAS 中的体力活动和/或肥胖；（4b）BP、体力活动和/或非 GWAS 中的肥胖。纳入的 GWAS 报告披露了用于多重检验的统计学显著阈值。搜索产生了 1422 份报告。其中，有 57 项试验符合标准，从中我们根据标准 1 提取了 11 个基因，根据标准 2 提取了 18 个基因，根据标准 3 提取了 28 个基因，根据标准 4a 提取了 27 个基因，根据标准 4b 提取了 29 个基因。我们还包括了从我们之前的工作中确定的 41 个基因。对这个系统地组装的基因特征集的外显子进行深度测序，是一种成本和时间效率高的方法，可以研究运动对血压的降压作用的基因组基础。
