Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY; Hospital for Special Surgery, Healthcare Research Institute, New York, NY.
Hospital for Special Surgery, Healthcare Research Institute, New York, NY.
J Arthroplasty. 2019 Sep;34(9):1999-2005. doi: 10.1016/j.arth.2019.02.023. Epub 2019 Feb 20.
Patient-reported outcome measures (PROMs) help assess therapeutic effectiveness. This study assessed the effect of advanced age on the Hip Disability and Osteoarthritis Outcome Score (HOOS) and Lower Extremity Activity Scale (LEAS) after total hip arthroplasty (THA).
A prospective cohort of patients underwent primary THA at our institution between May 2007 and December 2011. Exposure was age at the time of surgery and outcomes were HOOS and LEAS scores 2 and 5 years postsurgery. We used a multivariable longitudinal generalized estimating equation to elucidate the effect of age on PROM scores.
Our analysis of 3700 THA patients (mean age, 66 years; 56.4% female) demonstrated a decline in scores by age for the LEAS, HOOS Activities of Daily Living, and HOOS Sport and Recreation domains. There was also association between age and HOOS Symptoms and HOOS Quality of Life domains, but not between age and the HOOS Pain domain. Critical ages at which the relationship between age and outcome changed was 63 years for the HOOS Pain, Symptom, Activities of Daily Living, and Quality of Life domains, and 72 years for the HOOS Sport and Recreation domain and the LEAS.
Patients undergoing THA at older ages reported lower activity and sports and recreation scores than younger patients, but similar pain, symptoms, and quality of life scores. This knowledge can help physicians guide patients' expectations before THA. Our findings also indicate that PROM scores should be age adjusted when used for quality or value comparisons between hospitals or physicians.
患者报告的结局测量(PROMs)有助于评估治疗效果。本研究评估了年龄对全髋关节置换术(THA)后髋关节残疾和骨关节炎结局评分(HOOS)和下肢活动评分(LEAS)的影响。
本研究为前瞻性队列研究,纳入 2007 年 5 月至 2011 年 12 月在我院行初次 THA 的患者。暴露因素为手术时的年龄,结局指标为术后 2 年和 5 年的 HOOS 和 LEAS 评分。我们使用多变量纵向广义估计方程来阐明年龄对 PROM 评分的影响。
我们对 3700 例 THA 患者(平均年龄 66 岁,56.4%为女性)进行分析,结果显示 LEAS、HOOS 日常生活活动和 HOOS 运动和娱乐领域的评分随年龄的增长而下降。HOOS 症状和 HOOS 生活质量领域的评分也与年龄相关,但 HOOS 疼痛领域的评分与年龄无关。HOOS 疼痛、症状、日常生活活动和生活质量领域以及 LEAS 与年龄相关的结果变化的临界年龄分别为 63 岁和 72 岁。
接受 THA 的老年患者报告的活动和运动娱乐评分低于年轻患者,但疼痛、症状和生活质量评分相似。这一知识可以帮助医生在 THA 前指导患者的期望。我们的研究结果还表明,在使用 PROM 评分进行医院或医生之间的质量或价值比较时,应进行年龄调整。