Aránguez M I, Goya L, Pascual-Leone A M
Acta Endocrinol (Copenh). 1986 Dec;113(4):598-603. doi: 10.1530/acta.0.1130598.
Rats treated with cortisol, 0.5 mg one day after birth, show a decrease in body and organ weight and a decrease in pituitary TSH and GH when compared to controls together with a lack of response of TSH to TRH. These alterations have been previously found in animals treated with large doses of thyroxine, neo-T4 syndrome, in both populations a brain underdevelopment has been observed. Plasma insulin in cortisol-treated animals was higher (P less than 0.01) than in the controls at 8 and 12 days of life and lower at 22 days (P less than 0.001). Plasma ketone bodies were increased significantly at 8 but not at 12 and 22 days of life in the cortisol treated animals. Liver glycogen was higher than in controls at 2, 4, 6 days of life and lower at 8, 12 and 22 days. Blood glucose was higher than in controls at 2, 4 days and lower at 6, 8, 12 and 22 days of life. The timing of metabolic events is important for the adaptation and development of the post-natal animal. The perturbances in carbohydrate metabolism in suckling rats were also previously found in neo-T4 rats during the period when the brain growth spurt and energy need are the greatest; but in the rats treated with cortisol the timing of the alterations was different. This different timing of the metabolic perturbances could correlate with a different maturation in cerebral tissue found in histological studies in the two populations.
出生后一天接受0.5毫克皮质醇治疗的大鼠，与对照组相比，其体重和器官重量下降，垂体促甲状腺激素（TSH）和生长激素（GH）减少，且TSH对促甲状腺激素释放激素（TRH）无反应。这些改变先前在接受大剂量甲状腺素治疗的动物（新T4综合征）中也有发现，在这两种情况下均观察到大脑发育不全。皮质醇治疗组动物在出生后第8天和第12天的血浆胰岛素水平高于对照组（P<0.01），而在第22天则低于对照组（P<0.001）。皮质醇治疗组动物在出生后第8天血浆酮体显著增加，但在第12天和第22天未增加。肝糖原在出生后第2、4、6天高于对照组，而在第8、12和22天则低于对照组。血糖在出生后第2、4天高于对照组，而在第6、8、12和22天则低于对照组。代谢事件的时间安排对新生动物的适应和发育很重要。先前在新T4大鼠大脑生长突增和能量需求最大的时期也发现了哺乳大鼠碳水化合物代谢的紊乱；但在皮质醇治疗的大鼠中，改变的时间不同。这种代谢紊乱的不同时间可能与在这两组动物的组织学研究中发现的脑组织不同成熟度相关。
