激素和营养不良对新生大鼠大脑发育的影响。

Influence of hormones and undernutrition on brain development in newborn rats.

作者信息

Pascual-Leone A M, Escrivá F, Alvarez C, Goya L, Rodriguez C

出版信息

Biol Neonate. 1985;48(4):228-36. doi: 10.1159/000242175.

Abstract

High L-thyroxine (T4) and cortisol doses given to rats during the first 8 days of life and on the first day only respectively, produce decrease of body and brain weight and perturbances to brain energy substrates, i.e. glucose and ketone bodies. The same alterations are found in the undernourished rats from the prenatal period. The pituitary GH and TSH is decreased in the T4- and cortisol-injected animals. The plasma ACTH is decreased in the treated cortisol animals at 8, 12 and 22 days of life. The pituitary TSH content is reduced with respect to controls in the undernourished animals from 14 to 70 days of life. From the exposed experiments we suggest an alteration in the hypothalamic-pituitary complex in T4- and cortisol-treated rats, and describe the similarities between the three experimental models.

摘要

在出生后的头8天分别给大鼠高剂量的L-甲状腺素（T4），仅在第一天给大鼠高剂量的皮质醇，会导致大鼠体重和脑重下降，并扰乱脑能量底物，即葡萄糖和酮体。在产前营养不良的大鼠中也发现了同样的变化。注射T4和皮质醇的动物垂体生长激素（GH）和促甲状腺激素（TSH）减少。在接受皮质醇处理的动物中，出生后第8天、12天和22天血浆促肾上腺皮质激素（ACTH）减少。从出生后14天到70天，营养不良动物的垂体TSH含量相对于对照组降低。通过这些实验，我们推测T4和皮质醇处理的大鼠下丘脑-垂体复合体发生了改变，并描述了这三种实验模型之间的相似之处。