Jaksch Wolfgang, Likar Rudolf, Aigner Martin
Österreichische Schmerzgesellschaft, Wien, Österreich.
Abteilung für Anästhesiologie, Intensiv- und Schmerzmedizin, Wilhelminenspital der Stadt Wien, Montlearstraße 37, 1160, Wien, Österreich.
Wien Med Wochenschr. 2019 Nov;169(15-16):367-376. doi: 10.1007/s10354-019-0695-x. Epub 2019 Apr 12.
Although ketamine has been known and clinically applied for a long time, questions still arise around the many possible indications in which the anesthetic and analgesic substance could be used. In particular, these questions relate to new indications in which ketamine is used in low subanesthetic doses.The mechanism of action at the NMDA receptor clearly distinguishes ketamine from all other analgesics. Possible applications include the prevention of chronic postoperative pain as well as the treatment of neuropathic pain. With the treatment of refractory depression completely new therapeutic areas for ketamine could be established.
尽管氯胺酮已为人所知并在临床上应用了很长时间，但围绕这种麻醉和镇痛物质可能的多种应用仍存在问题。特别是，这些问题涉及氯胺酮以低于麻醉剂量使用的新应用。氯胺酮在N-甲基-D-天冬氨酸（NMDA）受体上的作用机制使其与所有其他镇痛药明显区分开来。可能的应用包括预防慢性术后疼痛以及治疗神经性疼痛。通过治疗难治性抑郁症，氯胺酮可能会开拓全新的治疗领域。
