Ephrins 和 Eph 受体信号在组织修复和纤维化中的作用。
Ephrins and Eph Receptor Signaling in Tissue Repair and Fibrosis.
机构信息
The Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
出版信息
Curr Rheumatol Rep. 2019 Apr 12;21(6):23. doi: 10.1007/s11926-019-0825-x.
PURPOSE OF REVIEW
Fibrosis is a pathological feature of many human diseases that affect multiple organs. The development of anti-fibrotic therapies has been a difficult endeavor due to the complexity of signaling pathways associated with fibrogenic processes, complicating the identification and modulation of specific targets. Evidence suggests that ephrin ligands and Eph receptors are crucial signaling molecules that contribute to physiological wound repair and the development of tissue fibrosis. Here, we discuss recent advances in the understanding of ephrin and Eph signaling in tissue repair and fibrosis.
RECENT FINDINGS
Ephrin-B2 is implicated in fibrosis of multiple organs. Intercepting its signaling may help counteract fibrosis. Ephrins and Eph receptors are candidate mediators of fibrosis. Ephrin-B2, in particular, promotes fibrogenic processes in multiple organs. Thus, therapeutic strategies targeting Ephrin-B2 signaling could yield new ways to treat organ fibrosis.
目的综述
纤维化是影响多种器官的许多人类疾病的病理特征。由于与纤维发生过程相关的信号通路的复杂性，抗纤维化疗法的发展一直是一项艰巨的任务，这使得特定靶点的识别和调节变得复杂。有证据表明，ephrin 配体和 Eph 受体是重要的信号分子，有助于生理伤口修复和组织纤维化的发展。在这里，我们讨论了在组织修复和纤维化中对 ephrin 和 Eph 信号的理解的最新进展。
最近的发现
ephrin-B2 与多种器官的纤维化有关。阻断其信号可能有助于对抗纤维化。ephrin 和 Eph 受体是纤维化的候选介质。特别是 Ephrin-B2，促进多种器官的纤维发生过程。因此，针对 Ephrin-B2 信号的治疗策略可能为治疗器官纤维化提供新方法。
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