Department of Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany.
Adv Exp Med Biol. 2019;1117:93-109. doi: 10.1007/978-981-13-3588-4_7.
Antimicrobial and cell-penetrating peptides are both classes of membrane-active peptides sharing similar physicochemical properties. Both kinds of peptides have attracted much attention owing to their specific features. AMPs disrupt cell membranes of bacteria and display urgently needed antibiotic substances with alternative modes of action. Since the multidrug resistance of bacterial pathogens is a more and more raising concern, AMPs have gained much interest during the past years. On the other side, CPPs enter eukaryotic cells without substantially affecting the plasma membrane. They can be used as drug delivery platforms and have proven their usefulness in various applications. However, although both groups of peptides are quite similar, their intrinsic activity is often different, and responsible factors are still in discussion. The aim of this chapter is to summarize and shed light on recent findings and concepts dealing with differences and similarities of AMPs and CPPs and to understand these different functions.
抗菌肽和细胞穿透肽都属于膜活性肽，具有相似的物理化学性质。由于具有独特的特性，这两种肽都引起了广泛关注。抗菌肽破坏细菌的细胞膜，并显示出具有急需的抗生素作用模式的物质。由于细菌病原体的多药耐药性越来越受到关注，抗菌肽在过去几年中受到了广泛关注。另一方面，CPP 进入真核细胞而不会对质膜产生实质性影响。它们可用作药物输送平台，并已在各种应用中证明了其有用性。然而，尽管这两组肽非常相似，但它们的内在活性通常不同，负责的因素仍在讨论中。本章的目的是总结和阐明有关抗菌肽和细胞穿透肽差异和相似之处的最新发现和概念，并了解这些不同的功能。
