Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2019 Feb 1;22(2):65-70.
Our aim was to determine the association between age at menarche (AAM) and breast cancer adjusted for recall bias (misclassification) in AAM.
We have used data provided from a case-control study conducted in Iran from 2005 to 2009. The cases and controls were frequency matched based on 5-year age groups and region of residence. First, logistic regression was conducted to estimate the odds ratio (OR) and second, Bayesian analysis was applied to estimate the ORs adjusted for misclassification.
The study was conducted on 880 cases and 998 controls. In the assumption of no correction for recall bias on self-reported AAM, the OR was 1.36 (95% Credible Interval (0.98, 1.90). Based on a sensitivity value = 71% and a specificity value = 81% (the indices about the ratio of true recall of AAM) for the case and control groups (as the first scenario), the AAM ≤ 12 years of age was associated with a lower OR for breast cancer by 1.23 (95% Credible Interval: 0.50, 3.13). In the other scenario, with consideration of 100% sensitivity and specificity of self- reported AAM in the case group, and 71% and 81% sensitivity and specificity of the item in the control group, the related OR between breast cancer and AAM was found increased to 2.96 (95% Credible Interval: 0.75, 7.66).
After adjustment for misclassification related to recall bias, this study provides evidence that the self-reported mode of AAM has a moderate impact on calculation of the OR.
本研究旨在确定初潮年龄（AAM）与乳腺癌之间的关联，并调整 AAM 回忆偏倚（分类错误）的影响。
我们使用了 2005 年至 2009 年在伊朗进行的一项病例对照研究的数据。病例和对照按 5 岁年龄组和居住地进行频数匹配。首先，我们进行了逻辑回归以估计比值比（OR），其次，我们应用贝叶斯分析来估计校正分类错误后的 OR。
本研究纳入了 880 例病例和 998 例对照。在未校正自我报告的 AAM 回忆偏倚的情况下，OR 为 1.36（95%可信区间为 0.98，1.90）。基于病例组和对照组的敏感性值=71%和特异性值=81%（关于 AAM 真实回忆率的指数）（作为第一方案），AAM≤12 岁与乳腺癌的较低 OR 相关，OR 值为 1.23（95%可信区间：0.50，3.13）。在另一种情况下，考虑到病例组中 AAM 的自我报告具有 100%的敏感性和特异性，而对照组中该项目的敏感性和特异性分别为 71%和 81%，乳腺癌与 AAM 之间的相关 OR 增加至 2.96（95%可信区间：0.75，7.66）。
校正与回忆偏倚相关的分类错误后，本研究提供了证据表明，自我报告的 AAM 模式对 OR 的计算有中度影响。
