Serafini P, Tan T, Norbryhn G
Am J Obstet Gynecol. 1986 Dec;155(6):1236-9. doi: 10.1016/0002-9378(86)90151-1.
Periovulatory steroidal dynamics in women undergoing ovulation induction with clomiphene citrate and human menopausal gonadotropin were studied in 31 women with tubal blockage. Serum estradiol levels were significantly reduced 36 hours after human chorionic gonadotropin administration (from 1792 +/- 162 to 926 +/- 132 pg/ml, p less than 0.001). Peripheral levels of testosterone and androstenedione did not change during this periovulatory time. Progesterone and 17 alpha-hydroxyprogesterone, as anticipated, significantly increased with an early rise noted within the first 8 hours of human chorionic gonadotropin administration (p less than 0.001). A significant reduction of the ratios of the steroidal pairs 17 alpha-hydroxyprogesterone-progesterone (17 alpha-hydroxylase) and androstenedione-17 alpha-hydroxyprogesterone (17,20-desmolase) was observed after human chorionic gonadotropin injection (p less than 0.001). Aromatase activity appeared to be inhibited because of a significant reduction in the estradiol/testosterone ratio 34 to 36 hours after human chorionic gonadotropin administration. Thus human chorionic gonadotropin, which triggers ovulation in women treated by clomiphene citrate-human menopausal gonadotropin, appears to partially reduce aromatizable substrate as well as inhibit aromatase activity.
对31名输卵管阻塞的女性进行了研究，以观察她们在使用枸橼酸氯米芬和人绝经期促性腺激素诱导排卵过程中的围排卵期甾体动力学。注射人绒毛膜促性腺激素36小时后，血清雌二醇水平显著降低（从1792±162降至926±132 pg/ml，p<0.001）。在这个围排卵期，外周睾酮和雄烯二酮水平没有变化。正如预期的那样，孕酮和17α-羟孕酮显著升高，在注射人绒毛膜促性腺激素的前8小时内就出现了早期升高（p<0.001）。注射人绒毛膜促性腺激素后，观察到甾体对17α-羟孕酮-孕酮（17α-羟化酶）和雄烯二酮-17α-羟孕酮（17,20-裂解酶）的比值显著降低（p<0.001）。由于注射人绒毛膜促性腺激素34至36小时后雌二醇/睾酮比值显著降低，芳香化酶活性似乎受到抑制。因此，在接受枸橼酸氯米芬-人绝经期促性腺激素治疗的女性中触发排卵的人绒毛膜促性腺激素，似乎会部分减少可芳香化的底物并抑制芳香化酶活性。
