Wolff J, Carl P, Clausen T G, Mikkelsen B O
Anaesthesia. 1986 Oct;41(10):1001-6. doi: 10.1111/j.1365-2044.1986.tb12741.x.
In a double-blind randomised study, 100 women who underwent induced abortion under midazolam anaesthesia were given the benzodiazepine antagonist Ro 15-1788 or placebo after termination of anaesthesia. Recovery was assessed by means of a modified Steward coma scale. Following incremental doses of Ro 15-1788, 56% of the patients were fully awake within 3 minutes and 92% after 5 minutes, which was significant compared to the placebo group. The median duration of amnesia was 91 minutes after Ro 15-1788 compared to 121 minutes in the placebo group (p less than 0.001). The median dose of Ro 15-1788 was 0.4 mg. A slight positive correlation between total dose of Ro 15-1788 and total amount of midazolam was found. Nausea and/or vomiting were found to be more frequent in the Ro 15-1788 group, but otherwise we found no differences between groups with regard to either side effects or cardiorespiratory function. Ro 15-1788 is evidently an effective antagonist to the sedation induced by midazolam.
在一项双盲随机研究中，100名在咪达唑仑麻醉下接受人工流产的女性在麻醉结束后被给予苯二氮䓬拮抗剂Ro 15 - 1788或安慰剂。通过改良的Steward昏迷量表评估恢复情况。给予递增剂量的Ro 15 - 1788后，56%的患者在3分钟内完全清醒，5分钟后92%完全清醒，与安慰剂组相比有显著差异。Ro 15 - 1788组遗忘的中位持续时间为91分钟，而安慰剂组为121分钟（p小于0.001）。Ro 15 - 1788的中位剂量为0.4毫克。发现Ro 15 - 1788的总剂量与咪达唑仑的总量之间存在轻微正相关。在Ro 15 - 1788组中恶心和/或呕吐更为常见，但在副作用或心肺功能方面，我们未发现两组之间存在差异。Ro 15 - 1788显然是咪达唑仑诱导镇静的有效拮抗剂。
