Alon E, Baitella L, Hossli G
Br J Anaesth. 1987 Apr;59(4):455-8. doi: 10.1093/bja/59.4.455.
The actions and side effects of the benzodiazepine antagonist Ro 15-1788 were evaluated in a randomized double-blind clinical study in which midazolam was used as an anaesthetic agent. Sixty women who underwent laparoscopy were treated with Ro 15-1788 or with placebo after the surgical procedure. Ro 15-1788 reversed the hypnotic effect of midazolam within a few minutes. The patients were alert, co-operative, oriented and had good recall of events after awakening. The effects were statistically better than placebo for up to 30 min after administration. Arterial pressure and heart rate remained stable and there were no significant side effects. The availability of Ro 15-1788 allows effective reversal of midazolam when this is used during general anaesthesia.
在一项随机双盲临床研究中，以咪达唑仑作为麻醉剂，对苯二氮䓬拮抗剂Ro 15 - 1788的作用及副作用进行了评估。60名接受腹腔镜检查的女性在手术结束后接受了Ro 15 - 1788或安慰剂治疗。Ro 15 - 1788在几分钟内逆转了咪达唑仑的催眠作用。患者苏醒后警觉、配合、定向力正常，对事件有良好的回忆。给药后长达30分钟，其效果在统计学上优于安慰剂。动脉压和心率保持稳定，且无明显副作用。当在全身麻醉期间使用咪达唑仑时，Ro 15 - 1788的可用性可实现对其的有效逆转。
