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Health Serv Outcomes Res Methodol. 2013 Mar;13(1):39-57.
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Studying Multivariate Change Using Multilevel Models and Latent Curve Models.使用多层模型和潜在曲线模型研究多变量变化。
Multivariate Behav Res. 1997 Jul 1;32(3):215-53. doi: 10.1207/s15327906mbr3203_1.
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Classifying human audiometric phenotypes of age-related hearing loss from animal models.从动物模型中分类与年龄相关的听力损失的人类听力表型。
J Assoc Res Otolaryngol. 2013 Oct;14(5):687-701. doi: 10.1007/s10162-013-0396-x. Epub 2013 Jun 6.
4
Order-restricted inference for multivariate longitudinal data with applications to the natural history of hearing loss.有序限制推断在多变量纵向数据中的应用，以及在听力损失自然史中的应用。
Stat Med. 2012 Jul 20;31(16):1761-73. doi: 10.1002/sim.5335.
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The analysis of multivariate longitudinal data: a review.多变量纵向数据分析：综述。
Stat Methods Med Res. 2014 Feb;23(1):42-59. doi: 10.1177/0962280212445834. Epub 2012 Apr 20.
6
Cognitive, health, and sociodemographic predictors of longitudinal decline in hearing acuity among older adults.认知、健康和社会人口因素对老年人听力敏锐度纵向下降的预测。
J Gerontol A Biol Sci Med Sci. 2012 Sep;67(9):997-1003. doi: 10.1093/gerona/gls066. Epub 2012 Mar 13.
7
Comparison of imputation methods for handling missing covariate data when fitting a Cox proportional hazards model: a resampling study.缺失协变量数据处理的填补方法在 Cox 比例风险模型拟合中的比较：重抽样研究。
BMC Med Res Methodol. 2010 Dec 31;10:112. doi: 10.1186/1471-2288-10-112.
8
Longitudinal changes in hearing sensitivity among men: the Veterans Affairs Normative Aging Study.男性听力灵敏度的纵向变化：退伍军人事务正常老化研究。
J Acoust Soc Am. 2010 Oct;128(4):1992-2002. doi: 10.1121/1.3466878.
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Constrained inference in mixed-effects models for longitudinal data with application to hearing loss.混合效应模型在纵向数据中的约束推断及其在听力损失中的应用。
Biostatistics. 2011 Apr;12(2):327-40. doi: 10.1093/biostatistics/kxq051. Epub 2010 Aug 18.
10
Cumulative lead exposure and age-related hearing loss: the VA Normative Aging Study.累积铅暴露与年龄相关性听力损失：退伍军人事务部正常老化研究。
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对多个频率下纵向测量的多变量听力阈值进行联合建模。

Joint modeling of multivariate hearing thresholds measured longitudinally at multiple frequencies.

作者信息

Gebregziabher Mulugeta, Eckert Mark A, Matthews Lois J, Teklehaimanot Abeba A, Dubno Judy R

机构信息

Department of Public Health Sciences, Medical University of South Carolina, Charleston, USA.

Department of Otolaryngology, Medical University of South Carolina, Charleston, USA.

出版信息

Commun Stat Theory Methods. 2018;47(22):5418-5434. doi: 10.1080/03610926.2017.1395045. Epub 2018 Mar 7.

DOI:10.1080/03610926.2017.1395045
PMID:30983686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6456904/
Abstract

Pure-tone thresholds are used to estimate hearing acuity and, when measured longitudinally, can characterize age-related changes in hearing. Measured at multiple-frequencies, multiple-irregular time points, for right and left ears, these longitudinal studies of age-related hearing loss produce data of inherent complexity due to: 1) multivariate outcomes at different frequencies; 2) longitudinal measurements taken at subject-specific time intervals; and 3) inter-ear correlations due to clustering and nesting. To address limitations in existing methods, we propose a multivariate generalized linear mixed model(mGLMM) and assess its performance. We demonstrate its application using a unique dataset from a cohort study of age-related hearing loss.

摘要

纯音阈值用于评估听力敏锐度，纵向测量时可表征与年龄相关的听力变化。这些关于年龄相关性听力损失的纵向研究在多个频率、多个不规则时间点对左右耳进行测量，由于以下原因产生了具有内在复杂性的数据：1）不同频率下的多变量结果；2）在个体特定时间间隔进行的纵向测量；3）由于聚类和嵌套导致的耳间相关性。为了解决现有方法的局限性，我们提出了一种多变量广义线性混合模型（mGLMM）并评估其性能。我们使用来自一项年龄相关性听力损失队列研究的独特数据集展示了它的应用。