抗IgE对IgE致敏的人肺泡巨噬细胞的刺激不受色甘酸钠的影响。

Stimulation of IgE sensitized human alveolar macrophages by anti-IgE is unaffected by sodium cromoglycate.

作者信息

Fuller R W, MacDermot J

出版信息

Clin Allergy. 1986 Nov;16(6):523-6. doi: 10.1111/j.1365-2222.1986.tb01990.x.

DOI:10.1111/j.1365-2222.1986.tb01990.x

Abstract

Sodium cromoglycate is an effective prophylactic in the treatment of asthma. However, its mechanism of action is still uncertain. The release of thromboxane B2 and N-acetyl-beta-D-glucosaminidase activity was measured from human alveolar macrophages sensitized with human myeloma IgE. Cells were challenged with rabbit affinity purified anti-IgE (no activity against IgG) in the absence or presence of sodium cromoglycate (10(-4)-10(-8)M). There was no change in the release of either thromboxane B2 or N-acetyl-beta-D-glucosaminidase in the presence of sodium cromoglycate at these concentrations.

摘要

色甘酸钠是治疗哮喘的一种有效预防性药物。然而，其作用机制仍不确定。用人类骨髓瘤IgE致敏的人肺泡巨噬细胞中，测定了血栓素B2的释放和N - 乙酰 - β - D - 氨基葡萄糖苷酶活性。在不存在或存在色甘酸钠（10⁻⁴ - 10⁻⁸M）的情况下，用兔亲和纯化的抗IgE（对IgG无活性）刺激细胞。在这些浓度下，色甘酸钠存在时，血栓素B2或N - 乙酰 - β - D - 氨基葡萄糖苷酶的释放均无变化。