Smith E A, Kahaleh M B, LeRoy E C
Clin Exp Rheumatol. 1986 Oct-Dec;4(4):341-5.
A defective acute phase response of scleroderma patients following intravenous PGE1 infusion has been reported. Serum C-reactive protein levels in scleroderma patients before and after a seventy-two hour infusion of either PGE1 or placebo were measured in the present study. The mean baseline serum CRP level in scleroderma patients was significantly greater than in normal controls (12 +/- 9.0 mcg/ml vs 1.4 +/- 1.7 mcg/ml) (p less than 0.001). Before the intravenous infusion, the PGE1-treated and placebo-treated groups had mean serum CRP concentrations of 14 +/- 9 and 10 +/- 9 mcg/ml, respectively. After the three-day infusion, these values were 109 +/- 75 and 11 +/- 10 mcg/ml (p less than 0.01). Scleroderma patients appeared to have two types of response to PGE1. Three patients had large increases (mean = 167 +/- 32 mcg/ml) and three had smaller increases (mean = 22 +/- 17) (p less than 0.005). The patients with greater increases had disease of shorter duration and greater cutaneous involvement. Overall, the acute phase response appears to be intact in scleroderma patients, but may differ in degree.
据报道，硬皮病患者静脉输注前列腺素E1（PGE1）后急性期反应存在缺陷。本研究测量了硬皮病患者在输注PGE1或安慰剂72小时前后的血清C反应蛋白水平。硬皮病患者的平均基线血清CRP水平显著高于正常对照组（12±9.0 mcg/ml对1.4±1.7 mcg/ml）（p<0.001）。静脉输注前，PGE1治疗组和安慰剂治疗组的平均血清CRP浓度分别为14±9和10±9 mcg/ml。三天输注后，这些值分别为109±75和11±10 mcg/ml（p<0.01）。硬皮病患者对PGE1似乎有两种反应类型。三名患者CRP大幅升高（平均=167±32 mcg/ml），三名患者升高幅度较小（平均=22±17）（p<0.005）。CRP升高幅度较大的患者病程较短，皮肤受累程度较重。总体而言，硬皮病患者的急性期反应似乎是完整的，但程度可能有所不同。
