环孢素和泼尼松龙联合治疗作为顽固性地图状脉络膜视网膜病变的一种潜在治疗策略。
Cyclosporine and prednisolone combination therapy as a potential therapeutic strategy for relentless placoid chorioretinitis.
作者信息
Uraki Takehiko, Namba Kenichi, Mizuuchi Kazuomi, Iwata Daiju, Ohno Shigeaki, Kitaichi Nobuyoshi, Ishida Susumu
机构信息
Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan.
出版信息
Am J Ophthalmol Case Rep. 2019 Mar 23;14:87-91. doi: 10.1016/j.ajoc.2019.03.005. eCollection 2019 Jun.
PURPOSE
Relentless placoid chorioretinitis (RPC) is a new disease concept that was proposed by Jones et al. in 2000. Some cases of RPC have been reported; however, a treatment strategy has not yet been established. We report herein four cases of patients diagnosed with RPC.
OBSERVATIONS
We experienced four cases of RPC in patients aged 24-51 years. All patients exhibited retinal lesions similar to that seen in acute posterior multifocal placoid pigment epitheliopathy or serpiginous choroiditis from the posterior pole to the surrounding region. Although patients underwent systemic prednisolone (PSL) therapy, recurrence was observed and the retinal scar formation was progressive; they were then diagnosed with RPC. In all cases, cyclosporine (CyA) was administered in addition to PSL, no recurrence was observed thereafter.
CONCLUSIONS AND IMPORTANCE
RPC is a rare disease, and a treatment strategy has not yet been established. CyA and PSL combination therapy is considered to be effective in the treatment of RPC.
目的
顽固性扁平状脉络膜视网膜病变（RPC）是琼斯等人于2000年提出的一种新的疾病概念。已有一些RPC病例的报道；然而，尚未确立治疗策略。我们在此报告4例被诊断为RPC的患者。
观察结果
我们诊治了4例年龄在24至51岁之间的RPC患者。所有患者均表现出从后极部至周边区域类似于急性后极部多发性扁平状色素上皮病变或匐行性脉络膜炎所见的视网膜病变。尽管患者接受了全身性泼尼松龙（PSL）治疗，但仍观察到复发且视网膜瘢痕形成呈进行性；随后他们被诊断为RPC。在所有病例中，除PSL外还给予了环孢素（CyA），此后未观察到复发。
结论与意义
RPC是一种罕见疾病，尚未确立治疗策略。CyA与PSL联合治疗被认为对RPC治疗有效。
Zotero 插件