Edwards M S
Clin Neurosurg. 1986;33:347-57.
Clinical results for in utero treatment of ventriculomegaly are not impressive; results may improve, however, with new techniques and more experience. Nonetheless, even in the best of hands, it is not always possible to identify associated and sometimes fatal congenital abnormalities on high resolution obstetric ultrasonograms, and not enough is known of the natural history of CNS congenital disease, in particular of ventriculomegaly, to select the appropriate fetus for in utero treatment. Results of animal studies are encouraging, but more work is needed to define the pathophysiology, knowledge of which might allow selection of the appropriate fetus and treatment modality.
宫内治疗脑室扩大的临床结果并不理想；不过，随着新技术的出现和经验的增加，结果可能会有所改善。尽管如此，即使是技术最娴熟的医生，也并非总能在高分辨率产科超声检查中识别出相关的、有时甚至是致命的先天性异常，而且对于中枢神经系统先天性疾病，尤其是脑室扩大的自然病史了解不足，难以选择合适的胎儿进行宫内治疗。动物研究的结果令人鼓舞，但还需要更多工作来明确其病理生理学，了解这些知识可能有助于选择合适的胎儿和治疗方式。
