Sy F S, Osteria T S, Opiniano V, Gler S
Contraception. 1986 Sep;34(3):283-94. doi: 10.1016/0010-7824(86)90009-0.
A prospective study was undertaken to determine the effect on liver function tests of a combined oral contraceptive containing norethisterone 1 mg and mestranol 0.05 mg, in women with schistosomiasis japonica in Leyte, Philippines. Women who volunteered and met the standard criteria for oral contraception, with and without infection, were followed for six months of pill intake. Concurrently, non-pill users, both infected and uninfected, were similarly followed. Baseline and six-month liver function tests were compared. Of the 466 subjects admitted in the study, 383 completed six months, and 83 discontinued. At the start of the study, there were no significant differences among the four groups in liver function tests except that the infected women had a higher total protein and alkaline phosphatase, and lower alanine aminotransferase levels. After six months, the only statistically significant finding was a lesser decrease in total protein among the infected pill users compared to the uninfected pill users. This finding was not clinically significant since there was no associated clinical complications; there were fewer number of subjects with abnormal values at the sixth month; and the mean values of this variable remained within normal limits. Our findings show that the use of low dose progestin and estrogen oral contraceptive in the presence of mild schistosomiasis japonica infection does not appear to have adverse effect on liver function tests of young women after six months of contraceptive use.
在菲律宾莱特岛，针对感染日本血吸虫病的女性，开展了一项前瞻性研究，以确定含1毫克炔诺酮和0.05毫克炔雌醇甲醚的复方口服避孕药对肝功能检查的影响。符合口服避孕药标准的自愿参与的感染和未感染女性，服用避孕药6个月并接受随访。同时，对感染和未感染的非服药女性进行类似随访。比较基线和6个月时的肝功能检查结果。该研究纳入的466名受试者中，383人完成了6个月的研究，83人中断。研究开始时，四组之间的肝功能检查无显著差异，只是感染女性的总蛋白和碱性磷酸酶较高，谷丙转氨酶水平较低。6个月后，唯一具有统计学意义的发现是，与未感染的服药女性相比，感染的服药女性总蛋白下降较少。这一发现无临床意义，因为没有相关临床并发症；第6个月时异常值的受试者较少；该变量的平均值仍在正常范围内。我们的研究结果表明，轻度日本血吸虫病感染的年轻女性使用低剂量孕激素和雌激素口服避孕药6个月后，似乎对肝功能检查没有不良影响。
