用于咔唑和环戊并[b]吲哚合成的取代基导向钯-烯反应
Substituent-Guided Palladium-Ene Reaction for the Synthesis of Carbazoles and Cyclopenta[ b]indoles.
作者信息
Yadav Sonu, Hazra Raju, Singh Animesh, Ramasastry S S V
机构信息
Organic Synthesis and Catalysis Lab, Department of Chemical Sciences , Indian Institute of Science Education and Research (IISER) Mohali , Sector 81, Manauli PO , S. A. S. Nagar , Punjab 140306 , India.
出版信息
Org Lett. 2019 May 3;21(9):2983-2987. doi: 10.1021/acs.orglett.9b00410. Epub 2019 Apr 15.
An efficient palladium-catalyzed intramolecular Trost-Oppolzer type Alder-ene strategy was developed for the synthesis of carbazoles and cyclopenta[ b]indoles from easily accessible(3-allyl-1 H-indol-2-yl)methyl acetates. This strategy was extended for the synthesis of naphthalenes and dibenzobenzofurans as well. In addition, a short synthesis of antibacterial and antifungal natural product glycozoline and its analogues was also achieved.
开发了一种高效的钯催化分子内特罗斯特-奥波泽尔型烯反应策略，用于从易于获得的（3-烯丙基-1H-吲哚-2-基）甲基乙酸酯合成咔唑和环戊并[b]吲哚。该策略还扩展到萘和二苯并苯并呋喃的合成。此外，还实现了抗菌和抗真菌天然产物糖唑啉及其类似物的简短合成。
Zotero 插件