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美国儿科患者的阿片类药物处方模式。

Opioid-prescribing Patterns for Pediatric Patients in the United States.

机构信息

Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA.

出版信息

Clin J Pain. 2019 Jun;35(6):515-520. doi: 10.1097/AJP.0000000000000707.

DOI:10.1097/AJP.0000000000000707
PMID:30985396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6782052/
Abstract

BACKGROUND AND OBJECTIVES

The opioid crisis in America affects both adults and children. However, knowledge about the epidemiology of the opioid crisis, opioid prescribing patterns, and the link between opioid prescribing and problematic opioid behaviors remain limited. Thus, children are often excluded from health care policies and guidelines aimed at curbing the opioid crises. The primary aim of this topical review is to provide a brief overview of the opioid crises affecting children, followed by a synopsis of recent research on opioid prescribing patterns and data on the links between legitimate opioid use and risk for problematic opioid use behaviors.

METHODS

This is a narrative review.

RESULTS

Opioid misuse is a public health crisis facing children and adolescents in the United States and serves as a key antecedent for other problematic opioid behaviors, including opioid use disorder, heroin use, and opioid overdose. Furthermore, the United States experienced a significant increase in opioid prescribing to children and adolescents as compared with prescribing rates before the year 2000. Yet, data on the associations between opioid prescribing patterns and risk for problematic opioid use remains limited.

DISCUSSION

There exist an urgent need to identify adolescents at increased risk for problematic opioid use behaviors following a receipt of medically prescribed opioids. The article closes with some general guidelines that providers may follow to reduce the risk of opioids in pediatric patients.

摘要

背景和目的

美国的阿片类药物危机不仅影响成年人,也影响儿童。然而,有关阿片类药物危机的流行病学、阿片类药物处方模式以及阿片类药物处方与问题性阿片类药物行为之间的联系的知识仍然有限。因此,儿童通常被排除在旨在遏制阿片类药物危机的医疗保健政策和指南之外。本次专题综述的主要目的是简要概述影响儿童的阿片类药物危机,随后概述最近关于阿片类药物处方模式的研究以及关于合法使用阿片类药物与出现问题性阿片类药物使用行为风险之间联系的数据。

方法

这是一篇叙述性综述。

结果

阿片类药物滥用是美国儿童和青少年面临的公共卫生危机,也是其他问题性阿片类药物行为的关键前兆,包括阿片类药物使用障碍、海洛因使用和阿片类药物过量。此外,与 2000 年之前的处方率相比,美国给儿童和青少年开的阿片类药物处方显著增加。然而,关于阿片类药物处方模式与出现问题性阿片类药物使用风险之间的关联的数据仍然有限。

讨论

目前迫切需要确定在接受医学上开具的阿片类药物后出现问题性阿片类药物使用行为的青少年。文章最后提出了一些一般准则,供提供者在减少儿科患者的阿片类药物风险时参考。

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Pediatrics. 2018 Jan;141(1). doi: 10.1542/peds.2017-2439. Epub 2017 Dec 4.
2
Drug Overdose Deaths Among Adolescents Aged 15-19 in the United States: 1999-2015.1999 - 2015年美国15至19岁青少年药物过量致死情况
NCHS Data Brief. 2017 Aug(282):1-8.
3
A Conceptual Framework for Understanding Unintended Prolonged Opioid Use.理解意外长期使用阿片类药物的概念框架。
Mayo Clin Proc. 2017 Dec;92(12):1822-1830. doi: 10.1016/j.mayocp.2017.10.010. Epub 2017 Nov 3.
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Opioid use disorder and misuse: A review of the epidemiology and medical implications for pediatric anesthesiologists.阿片类药物使用障碍与滥用:儿科麻醉医生的流行病学及医学影响综述
Paediatr Anaesth. 2017 Nov;27(11):1070-1076. doi: 10.1111/pan.13225.
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Impact of New York prescription drug monitoring program, I-STOP, on statewide overdose morbidity.纽约处方药监测计划(I-STOP)对全州过量用药发病率的影响。
Drug Alcohol Depend. 2017 Sep 1;178:348-354. doi: 10.1016/j.drugalcdep.2017.05.023. Epub 2017 Jun 23.
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Vital Signs: Changes in Opioid Prescribing in the United States, 2006-2015.生命体征:2006 - 2015年美国阿片类药物处方的变化
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J Pain. 2017 Oct;18(10):1270-1276. doi: 10.1016/j.jpain.2017.06.001. Epub 2017 Jun 24.
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Health Aff (Millwood). 2017 Apr 1;36(4):733-741. doi: 10.1377/hlthaff.2016.1141.
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