Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
Neuroscience. 2019 Jun 15;409:1-15. doi: 10.1016/j.neuroscience.2019.04.010. Epub 2019 Apr 12.
Perceptual decisions, especially for difficult stimuli, can be influenced by choices and outcomes in previous trials. However, it is not well understood how stimulus strength modulates the temporal characteristics as well as the magnitude of trial history influence. We addressed this question using a contrast detection task in freely moving mice. We found that, at lower as compared to higher stimulus contrast, the current choice of the mice was more influenced by choices and outcomes in the past trials and the influence emerged from a longer history. To examine the neural basis of stimulus strength-dependent history influence, we recorded from the secondary motor cortex (M2), a prefrontal region that plays an important role in cue-guided actions and memory-guided behaviors. We found that more M2 neurons conveyed information about choices on the past two trials at lower than at higher contrast. Furthermore, history-trial activity in M2 was important for decoding upcoming choice at low contrast. Thus, trial history influence of perceptual choice is adaptive to the strength of sensory evidence, which may be important for action selection in a dynamic environment.
感知决策，特别是对于困难的刺激，可能会受到先前试验中的选择和结果的影响。然而，目前还不清楚刺激强度如何调节时间特征，以及试验历史影响的大小。我们使用自由移动小鼠的对比检测任务来解决这个问题。我们发现，与较高的刺激对比度相比，较低的刺激对比度下，小鼠的当前选择受过去试验中的选择和结果的影响更大，而且这种影响来自更长的历史。为了研究刺激强度依赖性历史影响的神经基础，我们记录了来自次级运动皮层（M2）的神经元活动，M2 是一个在前导作用和记忆引导行为中起重要作用的前额叶区域。我们发现，在较低的对比度下，比在较高的对比度下，更多的 M2 神经元传递关于过去两个试验的选择信息。此外，M2 中的历史试验活动对于在低对比度下解码即将到来的选择很重要。因此，感知选择的试验历史影响是适应于感觉证据的强度的，这对于动态环境中的动作选择可能很重要。
