Piotto Stefano, Sessa Lucia, Piotto Andrea, Nardiello Anna Maria, Concilio Simona
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano SA, Italy.
Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano SA, Italy.
Life (Basel). 2019 Apr 4;9(2):33. doi: 10.3390/life9020033.
The emergence of life in a prebiotic world is an enormous scientific question of paramount philosophical importance. Even when life (in any sense we can define it) can be observed and replicated in the laboratory, it is only an indication of one possible pathway for life emergence, and is by no means be a demonstration of how life really emerged. The best we can hope for is to indicate plausible chemical-physical conditions and mechanisms that might lead to self-organizing and autopoietic systems. Here we present a stochastic simulation, based on chemical reactions already observed in prebiotic environments, that might help in the design of new experiments. We will show how the definition of simple rules for the synthesis of random peptides may lead to the appearance of networks of autocatalytic cycles and the emergence of memory.
在一个前生物世界中生命的出现是一个具有极其重要哲学意义的重大科学问题。即使生命（在我们能够定义的任何意义上）能够在实验室中被观察到并复制，这也仅仅表明了生命出现的一种可能途径，绝不是对生命真正出现方式的证明。我们所能期望的最好结果是指出可能导致自组织和自生成系统的合理化学物理条件及机制。在此，我们基于在前生物环境中已经观察到的化学反应进行了一次随机模拟，这可能有助于新实验的设计。我们将展示随机肽合成简单规则的定义如何可能导致自催化循环网络的出现以及记忆的产生。
