Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Institute of Medical Science and Technology, National Sun Yat-Sen University, Taiwan.
J Food Drug Anal. 2019 Apr;27(2):451-459. doi: 10.1016/j.jfda.2018.12.005. Epub 2019 Jan 8.
Foods and drinks have been adulterated with illicit drugs to facilitate criminal activities. Unfortunately, conventional analytical methods are incapable of rapidly characterizing these drugs in samples, as serious interferences from sample matrices must be removed through tedious and time-consuming pretreatment. Ambient ionization mass spectrometry (AMS) generally does not require sample pretreatment and is thus a suitable tool for directly and rapidly detecting illicit drugs in samples in different physical states. In this study, thermal desorption electrospray ionization mass spectrometry (TD-ESI/MS), an AMS technique, was utilized to efficiently characterize illicit drugs spiked in samples including drinks, powders, and jelly candies. To perform sensitive analysis, the mass analyzer was operated in multiple reaction monitoring mode to monitor the molecular and fragment ions of the target analytes. The time required to complete a typical TD-ESI/MS analysis was less than 30 s. The limits of detection (LODs) for illicit drugs were found to be 100 ppb in drinks, 100-1000 ppb in instant powders, and 1.3-6.5 ng/mm on stamp surfaces. FM2 and nitrazepam laced in the inner layer of a jelly candy were detected by TD-ESI/MS, showcasing the advantage of the technique for direct and rapid analysis as opposed to conventional methods.
食物和饮料被掺假非法药物，以方便犯罪活动。不幸的是，常规分析方法无法快速分析样品中的这些药物，因为必须通过繁琐且耗时的预处理来消除样品基质的严重干扰。环境电离质谱（AMS）通常不需要样品预处理，因此是一种直接快速检测不同物理状态样品中非法药物的合适工具。在这项研究中，热解吸电喷雾电离质谱（TD-ESI/MS），一种 AMS 技术，被用于有效地分析包括饮料、粉末和果冻糖在内的样品中添加的非法药物。为了进行敏感分析，质量分析仪在多反应监测模式下运行，以监测目标分析物的分子和碎片离子。完成典型 TD-ESI/MS 分析所需的时间不到 30 秒。发现非法药物的检出限（LOD）在饮料中为 100ppb，即时粉末中为 100-1000ppb，邮票表面为 1.3-6.5ng/mm。通过 TD-ESI/MS 检测到果冻糖内层掺有 FM2 和硝西泮，展示了该技术直接快速分析的优势，而不是传统方法。
