Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY, 12180, USA.
Department of Chemistry and Biology, University of Siegen, Adolf-Reichwein-Straße 2, 57076, Siegen, Germany.
Anal Bioanal Chem. 2018 Jul;410(17):4061-4076. doi: 10.1007/s00216-018-1023-9. Epub 2018 Apr 21.
In this article, some recent trends and developments in ambient desorption/ionization mass spectrometry (ADI-MS) are reviewed, with a special focus on quantitative analyses with direct, open-air sampling. Accurate quantification with ADI-MS is still not routinely performed, but this aspect is considered of utmost importance for the advancement of the field. In fact, several research groups are devoted to the development of novel and optimized ADI-MS approaches. Some key trends include novel sample introduction strategies for improved reproducibility, tailored sample preparation protocols for removing the matrix and matrix effects, and multimode ionization sources. In addition, there is significant interest in quantitative mass spectrometry imaging. Graphical abstract Conceptual diagram of the ambient desorption/ionization mass spectrometry approach with different desorption/ionization probes.
本文综述了常压解吸/电离质谱（ADI-MS）的一些最新趋势和进展，特别关注直接、露天采样的定量分析。ADI-MS 的准确定量分析尚未常规进行，但这一方面被认为是该领域发展的重中之重。事实上，一些研究小组致力于开发新的和优化的 ADI-MS 方法。一些关键趋势包括改进重现性的新型样品引入策略、用于去除基质和基质效应的定制样品制备方案以及多模式电离源。此外，人们对定量质谱成像也非常感兴趣。
