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一名表现为运动神经病和上肢症状的患者因摄入铅污染鸦片导致铅中毒:病例报告

Lead Toxicity due to Ingestion of Lead-Contaminated Opium in a Patient Presenting with Motor Neuropathy and Upper Limb : A case report.

作者信息

Mirzaei Seyed M M, Akbari Ayob, Mehrpour Omid, Zamani Nasim

机构信息

Department of Neurology, Birjand University of Medical Sciences, Birjand, Iran.

Department of Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran.

出版信息

Sultan Qaboos Univ Med J. 2018 Nov;18(4):e529-e532. doi: 10.18295/squmj.2018.18.04.017. Epub 2019 Mar 28.

Abstract

Opium users may present with central or peripheral nervous system-related symptoms, gastrointestinal complications and anaemia; in such cases, lead poisoning should be suspected and chelation therapy initiated as soon as possible. We report a 64-year-old male patient with a 20-year history of opium addiction who was referred to the Imam Reza Hospital, Birjand, Iran, in 2017 with severe motor neuropathy and in both upper limbs. His primary symptoms were generalised weakness, abdominal and bone pain, constipation and lower limb paraesthesia that had started several months prior. In addition, he reported severe progressive bilateral of the upper limbs of one month's duration. A diagnosis of lead poisoning was confirmed by a blood lead level of 140 μg/dL. The patient underwent chelation therapy after which he improved significantly. At a one-year follow-up visit, he was neurologically intact and symptom-free.

摘要

鸦片使用者可能会出现与中枢或外周神经系统相关的症状、胃肠道并发症和贫血;在这种情况下,应怀疑铅中毒并尽快开始螯合疗法。我们报告一名64岁男性患者,有20年鸦片成瘾史,2017年因严重的运动神经病变被转诊至伊朗比尔詹德的伊玛目礼萨医院,其双上肢均有病变。他的主要症状是全身无力、腹部和骨骼疼痛、便秘以及下肢感觉异常,这些症状在数月前就已开始。此外,他报告称双上肢严重进行性无力,持续了一个月。血铅水平为140μg/dL,确诊为铅中毒。该患者接受了螯合疗法,之后病情显著改善。在一年的随访中,他神经功能正常,无症状。

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