Colletti R B, Trainer T D, Krawisz B R
J Pediatr Gastroenterol Nutr. 1986 Nov-Dec;5(6):990-4. doi: 10.1097/00005176-198611000-00032.
Valproate fulminant hepatotoxicity, usually fatal, is believed to be idiosyncratic and metabolic without an immunologic basis. There are no previous reports of a hypersensitivity reaction among numerous cases of fatal valproate fulminant hepatitis. Little is known about the electron microscopical features of valproate hepatitis. We report a case of reversible fulminant hepatitis attributable to valproate with clinical and histological characteristics of a hypersensitivity reaction. Electron microscopical findings included microvesicular steatosis with normal-appearing mitochondria.
丙戊酸盐暴发性肝毒性通常是致命的，被认为是特异质性和代谢性的，无免疫基础。在众多丙戊酸盐暴发性肝炎致死病例中，此前尚无超敏反应的报告。关于丙戊酸盐肝炎的电子显微镜特征知之甚少。我们报告一例由丙戊酸盐引起的可逆性暴发性肝炎病例，具有超敏反应的临床和组织学特征。电子显微镜检查结果包括微泡性脂肪变性，线粒体外观正常。
