Department of Neurology, Shengjing Hospital, China Medical University, Shenyang, China.
J Clin Pharm Ther. 2019 Oct;44(5):823-828. doi: 10.1111/jcpt.12838. Epub 2019 Apr 15.
Aspirin resistance refers to a patient's poor response to aspirin. There are many factors that can contribute to aspirin resistance, including single-nucleotide polymorphisms, medication compliance, drug-drug interactions and inflammation.
Recently, oxidative stress-induced 8-isoprostaglandin F2α has attracted considerable attention because it is considered as a mechanism of aspirin resistance in many diseases, including coronary artery disease, neurology system disease, metabolic syndrome, cancer, chronic obstructive pulmonary disease and chronic kidney disease. In these diseases, increased oxidative stress may promote platelet activation and reduce the efficacy of aspirin by producing excessive amounts of 8-isoprostaglandin F2α.
Given the wide clinical use of aspirin, it is essential to understand why some patients do not response to it. This article reviews current research on aspirin resistance mediated by oxidative stress-induced 8-isoprostaglandin F2α.
阿司匹林抵抗是指患者对阿司匹林反应不佳。有许多因素可导致阿司匹林抵抗，包括单核苷酸多态性、药物依从性、药物相互作用和炎症。
最近，氧化应激诱导的 8-异前列腺素 F2α引起了相当多的关注，因为它被认为是包括冠状动脉疾病、神经系统疾病、代谢综合征、癌症、慢性阻塞性肺疾病和慢性肾病在内的许多疾病中阿司匹林抵抗的机制。在这些疾病中，增加的氧化应激可能通过产生过多的 8-异前列腺素 F2α来促进血小板激活并降低阿司匹林的疗效。
鉴于阿司匹林的广泛临床应用，了解为什么有些患者对其没有反应是至关重要的。本文综述了目前关于氧化应激诱导的 8-异前列腺素 F2α介导的阿司匹林抵抗的研究。
