Zhu Jing-Bo, Wang Yong-Hua, Hu Zhong-Dong, Li Jun
Jiangsu Kanion Pharmaceutical Co., Ltd. Lianyungang 222001, China.
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(3):422-432. doi: 10.19540/j.cnki.cjcmm.20180921.002.
Stroke has become the second leading cause of death in the world, and the most common type is the ischemic stroke. Due to its rapid onset and complex conditions, ischemic stroke is a major neurological disorder that causes disability. Ischemic stroke mainly results from atherosclerosis, and the pathogenesis of ischemic stroke mainly includes energy metabolism disorders in the brain, the toxicity of excitatory amino acids, oxidative/nitrification stress, inflammatory response, apoptosis, and autophagy. With the characteristics of multi-component and multi-target, traditional Chinese medicine could be used to treat ischemic stroke at different stages. This article summarized the latest research progress on the pathogenesis of ischemic stroke and commonly used traditional Chinese medicine for treatment of ischemic stroke in order to provide references for the further research and clinical treatment of ischemic stroke.
中风已成为全球第二大致死原因,最常见的类型是缺血性中风。由于其发病迅速且病情复杂,缺血性中风是导致残疾的主要神经系统疾病。缺血性中风主要由动脉粥样硬化引起,其发病机制主要包括脑部能量代谢紊乱、兴奋性氨基酸毒性、氧化/硝化应激、炎症反应、细胞凋亡和自噬。中药具有多成分、多靶点的特点,可用于治疗缺血性中风的不同阶段。本文综述了缺血性中风发病机制及常用治疗缺血性中风的中药的最新研究进展,为缺血性中风的进一步研究和临床治疗提供参考。