Wu Dong-Xue, Huo Meng-Qi, Hou Ning, Li Jing, Liu Min, Zhang Yan-Ling, Qiao Yan-Jiang
State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.
Zhongguo Zhong Yao Za Zhi. 2019 Jan;44(2):205-211. doi: 10.19540/j.cnki.cjcmm.20180913.001.
The efficacy of traditional Chinese medicine is the therapeutic effect of the drug on the body. The nature of traditional Chinese medicine is a further generalization of the effect of efficacy,and there is an intrinsic relationship between efficacy and nature of traditional Chinese medicine. In this study,the nature-effect relationship is found on the whole level,through the research mode of " nature combination-targets of traditional Chinese medicine-modules of protein interaction network-efficiency". The results showed that the warm-pungent-liver protein interaction network mainly participated in lipid catabolic process,blood coagulation,platelet activation,heme oxidation,platelet degranulation,apoptotic process,acute inflammatory response to exert the effect of anti-tumor,antithrombotic,anti-myocardial ischemia and anti-inflammatory.
中药的功效是药物对机体的治疗作用。中药的药性是对功效作用的进一步概括，中药的功效与药性之间存在内在联系。本研究通过“药性组合-中药靶点-蛋白质相互作用网络模块-功效”的研究模式，从整体层面上发现药性-功效关系。结果表明，温热-肝蛋白质相互作用网络主要参与脂质分解代谢过程、血液凝固、血小板活化、血红素氧化、血小板脱颗粒、凋亡过程、急性炎症反应，从而发挥抗肿瘤、抗血栓、抗心肌缺血和抗炎作用。
