Ma Kun, Chen Yan-Xia, Dong Mei-Ling
Xiyuan Hospital,China Academy of Chinese Medical Sciences Beijing 100091,China.
Traditional Chinese Medicine Hospital of Huairou District Beijing 101400,China.
Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(6):1069-1074. doi: 10.19540/j.cnki.cjcmm.20181225.002.
The efficacy and safety of traditional Chinese medicine and acupuncture in the treatment of kidney-deficiency and bloodstasis perimenopausal sleep disorders were evaluated. A total of 67 subjects who completed the study were randomly divided into two groups. The traditional Chinese medicine group was orally given Bushen Huoxue Anshen Fang,and the acupuncture group was given acupuncture treatment. Both groups were treated for three consecutive courses of treatment,with a course of treatment of 30 days. The changes of PSQI score,improved Kupperman score,TCM syndromes,serum sex hormone,coagulation,routine blood and urine,liver and kidney function and electrocardiogram were observed before and after treatment. After treatment,the total effective rates of Chinese medicine group and acupuncture group were similar or respectively 91. 43% and 87. 50%. The scores of PSQI,improved Kupperman and TCM syndromes in both groups decreased significantly( P<0. 05). The effect of improving Kupperman score in TCM group was better than that in acupuncture group( P< 0. 01). The effect of improving PSQI and TCM syndromes was similar to that in acupuncture group. The levels of serum FSH and LH were decreased in both groups( P<0. 05),but with no significant difference between the two groups; the level of serum E2 was increased in both groups,but with no significant difference. Compared with before treatment,PT was increased in traditional Chinese medicine group( P<0. 05),but with no significant difference in APTT,TT and FIB before and after treatment; PT and TT were prolonged in acupuncture group( P<0. 05),but with no significant difference in APTT and FIB before and after treatment. The effect of improving PT and TT in the acupuncture group was better than that in the traditional Chinese medicine group( P<0. 05). The results showed that TCM and acupuncture had similar therapeutic effects on perimenopausal sleep disorder of kidney deficiency and blood stasis type,and were safe and reliable. The mechanism was related to the improvement of serum FSH and E2 levels.
评估了中药及针灸治疗肾虚血瘀型围绝经期睡眠障碍的疗效及安全性。共有67名完成研究的受试者被随机分为两组。中药组口服补肾活血安神方，针灸组给予针灸治疗。两组均连续治疗三个疗程，一个疗程为30天。观察治疗前后匹兹堡睡眠质量指数（PSQI）评分、改良Kupperman评分、中医证候、血清性激素、凝血指标、血常规、尿常规、肝肾功能及心电图的变化。治疗后，中药组和针灸组的总有效率相近，分别为91.43%和87.50%。两组的PSQI评分、改良Kupperman评分及中医证候评分均显著降低（P<0.05）。中药组改善Kupperman评分的效果优于针灸组（P<0.01）。改善PSQI及中医证候的效果与针灸组相似。两组血清促卵泡生成素（FSH）和促黄体生成素（LH）水平均降低（P<0.05），但两组间差异无统计学意义；两组血清雌二醇（E2）水平均升高，但差异无统计学意义。与治疗前比较，中药组凝血酶原时间（PT）升高（P<0.05），活化部分凝血活酶时间（APTT）、凝血酶时间（TT）及纤维蛋白原（FIB）治疗前后差异无统计学意义；针灸组PT及TT延长（P<0.05），APTT及FIB治疗前后差异无统计学意义。针灸组改善PT及TT的效果优于中药组（P<0.05）。结果表明，中药和针灸对肾虚血瘀型围绝经期睡眠障碍具有相似的治疗效果，且安全可靠。其机制与血清FSH及E2水平的改善有关。
