Institute for Translational Medicine , Medical College of Qingdao University , Dengzhou Road 38 , Qingdao 266021 , China.
Key Laboratory of Experimental Marine Biology , Institute of Oceanology, Chinese Academy of Sciences , Qingdao 266071 , China.
J Agric Food Chem. 2019 May 1;67(17):4709-4719. doi: 10.1021/acs.jafc.9b01667. Epub 2019 Apr 22.
Cancer is a significant disease burden worldwide. Chemotherapy is the mainstay of cancer treatment. Clinically used chemotherapeutic agents may elicit severe side effects. Remarkably, most of cancer cells develop chemoresistance after a period of treatment. Therefore, it is imperative to seek more effective agents without side effects. In recent years, increasing research efforts have attempted to identify natural agents that may be used alone or in combination with traditional therapeutics for cancer management. Resveratrol is a natural polyphenolic phytoalexin that can be found in various foods including blueberries, peanuts, and red wine. As a natural food ingredient, resveratrol possesses antioxidant, anti-inflammatory, and cardioprotective properties. Moreover, resveratrol exhibited promising effects in suppressing the initiation and progression of cancers. Noncoding RNAs (ncRNAs) have been universally accepted as vital regulators in cancer pathogenesis. The modulation of miRNAs and lncRNAs by resveratrol has been described. Thus, the mechanism involving the domination of ncRNA function is one of the keys to understand the anticancer effects of resveratrol. In this review, we focus on the antagonistic effects of resveratrol on cancer progression through regulation of miRNAs and lncRNAs. We also discuss the potential application of resveratrol in cancer management.
癌症是全球范围内一个重大的疾病负担。化疗是癌症治疗的主要手段。临床上使用的化疗药物可能会引起严重的副作用。值得注意的是，大多数癌细胞在经过一段时间的治疗后会产生耐药性。因此，迫切需要寻找更有效且无副作用的药物。近年来，越来越多的研究试图确定天然药物，这些药物可单独使用或与传统疗法联合用于癌症的治疗。白藜芦醇是一种天然多酚植物抗毒素，可在蓝莓、花生和红酒等各种食物中找到。作为一种天然食物成分，白藜芦醇具有抗氧化、抗炎和心脏保护特性。此外，白藜芦醇在抑制癌症的发生和发展方面表现出了良好的效果。非编码 RNA（ncRNA）已被普遍认为是癌症发病机制中的重要调节因子。白藜芦醇对 miRNA 和 lncRNA 的调节作用已经得到了描述。因此，ncRNA 功能调控的机制是理解白藜芦醇抗癌作用的关键之一。在这篇综述中，我们重点讨论了白藜芦醇通过调节 miRNA 和 lncRNA 对癌症进展的拮抗作用。我们还讨论了白藜芦醇在癌症管理中的潜在应用。
