Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima, Japan.
Nat Prod Res. 2020 Oct;34(20):2990-2992. doi: 10.1080/14786419.2019.1597352. Epub 2019 Apr 16.
Ophiobolin A, a metabolite of fungi, is known to induce cell death and have anticancer activity. Therefore, obtaining ophiobolin A has become an important aspect in studying activity with medicinal properties that are affected by it. Ophiobolin A-producing filamentous fungi are endophytic or infectious microbes that attack annual and short-cycle plants. Here we isolated the endophyte of , which is an annual plant that produces ophiobolin A. Results of this study have led to the identification of an endophytic filamentous fungus sp. with high ophiobolin A production (235 mg/L) in liquid culture after 21 days. Our findings further indicate that ophiobolin A-producing fungi live in short-cycle plants, and a method of finding the fungus is described.
蛇孢菌素 A 是一种真菌代谢产物，已知具有诱导细胞死亡和抗癌活性。因此，获得蛇孢菌素 A 已成为研究受其影响的药用活性的一个重要方面。产生蛇孢菌素 A 的丝状真菌是内生的或传染性的微生物，它们攻击一年生和短生命周期的植物。在这里，我们从一年生植物 中分离出内生真菌 ，它可以产生蛇孢菌素 A。这项研究的结果表明，在 21 天的液体培养后，内生丝状真菌 产生了高浓度的蛇孢菌素 A（235mg/L）。我们的发现进一步表明，产生蛇孢菌素 A 的真菌存在于短生命周期的植物中，并描述了一种寻找真菌的方法。
