Islam Tawhida, Ara Iffat, Islam Tariqul, Sah Pankaj Kumar, Almeida Ray Silva de, Matias Edinardo Fagner Ferreira, Ramalho Cícero Lucas Gomes, Coutinho Henrique Douglas M, Islam Muhammad Torequl
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh.
Department of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Brazil.
Curr Res Toxicol. 2023 May 13;4:100106. doi: 10.1016/j.crtox.2023.100106. eCollection 2023.
Datura metel L., a recognized poisonous plant in the Solanaceae family, is widely distributed in the world. Traditionally, D. metel is used in many diseases, including neurological and heart diseases; fever; catarrh; pain; diarrhea; skin diseases; chronic bronchitis; asthma; digestive disorders; and so on. It possesses many important phytochemicals that can be used to treat various types of diseases. This review aims at summarizing the traditional uses, phytochemical, biological, and toxicological profiles of D. metel based on the database reports. For this, an up-to-date (till March 20, 2023) search was made in the databases: PubMed, Google Scholar, Science Direct, Scopus, and MedLine, with relevant keywords for the published evidence. Findings suggest that the plant has many traditional uses, such as a cure for madness, epilepsy, psoriasis, heart diseases, diarrhea, mad dog bites, indigestion, etc. It possesses various important phytochemicals, including withanolides, daturaolone, datumetine, daturglycosides, ophiobolin A, baimantuoluoline A, and many others. D. metel has many important biological activities, including antioxidant, anti-inflammatory, anti-microbial, insecticidal, anti-cancer, anti-diabetic, analgesic, anti-pyretic, neurological, contraceptive, and wound healing capacity. In conclusion, the toxic plant, D. metel, can be considered a potential source of phyto-therapeutic lead compounds.
洋金花，一种茄科公认的有毒植物，在世界范围内广泛分布。传统上，洋金花被用于治疗多种疾病，包括神经系统疾病和心脏病；发热；黏膜炎；疼痛；腹泻；皮肤病；慢性支气管炎；哮喘；消化系统疾病等等。它含有许多重要的植物化学物质，可用于治疗各类疾病。本综述旨在根据数据库报告总结洋金花的传统用途、植物化学、生物学和毒理学概况。为此，我们在PubMed、谷歌学术、科学Direct、Scopus和MedLine等数据库中进行了最新（截至2023年3月20日）的搜索，使用相关关键词查找已发表的证据。研究结果表明，该植物有许多传统用途，如治疗疯癫、癫痫、牛皮癣、心脏病、腹泻、疯狗咬伤、消化不良等。它含有多种重要的植物化学物质，包括甾类内酯、洋金花醇酮、洋金花碱、洋金花糖苷、蛇孢菌素A、白曼陀罗碱A等等。洋金花具有许多重要的生物活性，包括抗氧化、抗炎、抗菌、杀虫、抗癌、抗糖尿病、镇痛、退热、对神经系统的作用、避孕和伤口愈合能力。总之，有毒植物洋金花可被视为植物治疗先导化合物的潜在来源。
