Evidente Antonio, Andolfi Anna, Cimmino Alessio, Vurro Maurizio, Fracchiolla Mariano, Charudattan Raghavan, Motta Andrea
Dipartimento di Scienze del Suolo della Pianta e dell'Ambiente, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.
Phytochemistry. 2006 Oct;67(20):2281-7. doi: 10.1016/j.phytochem.2006.07.016. Epub 2006 Sep 7.
Drechslera gigantea, a fungal pathogen isolated from large crabgrass (Digitaria sanguinalis) and proposed as a potential mycoherbicide of grass weeds, produces phytotoxic metabolites in liquid and solid cultures. Ophiobolin A and three minor ophiobolins i.e., 6-epi-ophiobolin A, 3-anhydro-6-epi-ophiobolin A and ophiobolin I were obtained from the liquid culture broths. Interestingly and unexpectedly, ophiobolins also appeared in cultures of this fungus and they were isolated together with the known ophiobolins B and J, and designed as ophiobolin E and 8-epi-ophiobolin J. They were characterized using essentially spectroscopic methods. It is noteworthy that D. gigantea produces such a plethora of bioactive organic substances. Some structure-activity relationship results are also discussed in this report.
巨大德氏霉，一种从大狗尾草（马唐）中分离出的真菌病原体，被提议作为杂草的潜在真菌除草剂，在液体和固体培养物中产生植物毒性代谢物。从液体培养肉汤中获得了蛇孢菌素A和三种次要的蛇孢菌素，即6-表蛇孢菌素A、3-脱水-6-表蛇孢菌素A和蛇孢菌素I。有趣且出乎意料的是，蛇孢菌素也出现在该真菌的培养物中，它们与已知的蛇孢菌素B和J一起被分离出来，并被命名为蛇孢菌素E和8-表蛇孢菌素J。它们主要通过光谱方法进行表征。值得注意的是，巨大德氏霉产生了如此大量的生物活性有机物质。本报告还讨论了一些构效关系结果。
