评估接触游离结晶二氧化硅工人的限制性肺病的非侵入性技术。
Non-invasive techniques to assess restrictive lung disease in workers exposed to free crystalline silica.
作者信息
Corradi Massimo, Folesani Giuseppina, Robuschi Benedetta, Selis Luisella, Riccelli Maria Grazia, Riccelli Maria Grazia, Andreoli Roberta, Pisi Roberta, Chetta Alfredo, Mutti Antonio
机构信息
Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy.
出版信息
Med Lav. 2019 Apr 19;110(2):83-92. doi: 10.23749/mdl.v110i2.7471.
OBJECTIVES
To compare the reliability of spirometry and body plethysmography in detecting restrictive lung disease in clay excavation workers exposed to free crystalline silica (FCS). The exhaled breath condensate (EBC) biomarkers of oxidative stress were also assessed in order to evaluate early lung damage.
METHODS
The study involved 62 workers (58 males and 4 females) at a company that extracts and processes clay.
RESULTS
Body plethysmography (total lung capacity below the lower normal limit) and spirometry respectively indicated restrictive pattern prevalence rates of 22.6% and 1.6%. EBC 4-hydroxynonenale levels were not sufficiently sensitive to highlight a restrictive deficit, but did distinguish low and high rates of occupational exposure. There was no correlation between plethysmography values and the intensity or duration of exposure.
CONCLUSIONS
Only one out of 14 cases of restrictive deficit diagnosed on the basis of body plethysmography values was also identified by means of spirometry. This finding supports the need to use body plethysmography in the health surveillance of clay workers exposed to FCS.
目的
比较肺活量测定法和体容积描记法在检测接触游离结晶二氧化硅（FCS）的粘土挖掘工人限制性肺病方面的可靠性。还评估了呼出气体冷凝物（EBC）氧化应激生物标志物，以评估早期肺损伤。
方法
该研究纳入了一家开采和加工粘土的公司的62名工人（58名男性和4名女性）。
结果
体容积描记法（总肺容量低于正常下限）和肺活量测定法分别显示限制性模式患病率为22.6%和1.6%。EBC中4-羟基壬烯醛水平对突出限制性缺陷不够敏感，但确实区分了低和高职业暴露率。体容积描记法值与暴露强度或持续时间之间没有相关性。
结论
在根据体容积描记法值诊断出的14例限制性缺陷病例中，只有1例也通过肺活量测定法得以识别。这一发现支持在对接触FCS的粘土工人进行健康监测时使用体容积描记法。
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