与细胞毒性T细胞前体协同作用的抗原特异性辅助性T细胞的体外生成。
In vitro generation of antigen-specific helper T cells that collaborate with cytotoxic T-cell precursors.
作者信息
Baum L L, Pilarski L M
出版信息
J Exp Med. 1978 Dec 1;148(6):1579-91. doi: 10.1084/jem.148.6.1579.
Abstract
Antigen-specific helper T cells are required in the generation of cytotoxic T cells from thymocyte precursors. We have demonstrated that these alloantigen-specific helper cells can be generated in vitro and that both the quantity and quality of the helpers appear to be superior to the help obtained from unprimed spleen cells. Optimal helper cell activity is produced at day two of culture when CBA splenic helper precursors are stimulated by irradiated allogeneic spleen cells. Helper cell precursors are antigen-specific cells which cannot be instructed to express forbidden receptor specificities and bear theta antigen on their surface. The helper effectors are radioresistant, theta-bearing, and antigen-specific cells.
摘要
从胸腺细胞前体产生细胞毒性T细胞需要抗原特异性辅助性T细胞。我们已经证明，这些同种异体抗原特异性辅助细胞可以在体外产生，而且辅助细胞的数量和质量似乎都优于从未经致敏的脾细胞获得的辅助作用。当CBA脾辅助前体细胞受到照射的同种异体脾细胞刺激时，在培养的第二天可产生最佳辅助细胞活性。辅助细胞前体是抗原特异性细胞，不能被诱导表达禁忌受体特异性，且其表面带有θ抗原。辅助效应细胞是抗辐射的、带有θ抗原的和抗原特异性细胞。
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